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FLASH GENE
Symbol HABP2 contributors: mct - updated : 17-03-2012
HGNC name hyaluronan binding protein 2
HGNC id 4798
Location 10q25.3      Physical location : 115.310.589 - 115.349.358
Synonym name
  • plasma hyaluronan binding protein
  • factor VII activating protein
  • hepatocyte growth factor activator-like protein
  • factor seven-activating protease
  • hyaluronan-binding protein 2 27 kDa light chain alternate form
  • Synonym symbol(s) HABP, PHBP, HGFAL, FSAP
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 38.77 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC340699 10q25.3 similar to 1110018J23Rik protein PDCD4 10q24 programmed cell death 4 (neoplastic transformation inhibitor) SHOC2 10q25 soc-2 suppressor of clear homolog (C. elegans) ADRA2A 10q25 adrenergic, alpha-2A-, receptor KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1 AMACO 10q26.11 A-domain containing protein similar to matrilin and collagen STK6LP 10q25-q26 serine/threonine kinase 6-like pseudogene LOC390005 10 similar to AMACO FLJ14564 10q26.11 hypothetical protein FLJ14564 ABLIM1 10q25 actin binding LIM protein 1 LOC390006 10 similar to peptidylprolyl isomerase A (cyclophilin A) KIAA1600 10q26.11 KIAA1600 protein TRUB1 10q26.11 TruB pseudouridine (psi) synthase homolog 1 (E. coli) KIAA0534 10q26 KIAA0534 protein GFRA1 10q26 GDNF family receptor alpha 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 3019 62.7 560 - 1996 8827452
    13 - 2978 - 534 - 1996 8827452
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrinepancreas    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three epidermal growth factor (EGF)
  • a kringle domain
  • a serine protease domain
  • mono polymer heteromer , dimer
    isoforms Precursor circulates as a single-chain proenzyme (pro-PHBP), which is converted to an active, two-chain form through autoproteolysis
    HOMOLOGY
    interspecies homolog to murine Habp2
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY adhesion , enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • glycosaminoglycan binding activity
  • can activate coagulation factor VII and prourokinase and release the vasoactive peptide bradykinin by cleaving kininogen
  • undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA
  • negatively regulates vascular integrity via activation of protease-activated receptor/RHOA/RHO kinase signaling
  • serine protease implicated in proteolysis under inflammatory conditions
  • circulating serine protease with high homology to fibrinolytic enzymes
  • important role in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed by a 50kDa protein and a 17kDa protein joined by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaves single chain urokinase-type plasminogen activator
  • Histone binds to pro-PHBP (histone-mediated pro-PHBP activation results in bradykinin formation, which is implicated in septic shock)
  • cell & other
    REGULATION
    activated by histone that promotes pro-PHBP autoactivation
    Other polyamine leakage from legions through cell death or tissue injury may account for physiologically relevant pro-HABP2 activation
    regulation of its activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death (
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to carotid stenosis and deep venous thrombosis (DVT)
    Variant & Polymorphism other
  • association of the 1601GA genotype with incidence and progression of carotid stenosis and deep venous thrombosis (DVT)
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    potentially useful therapeutic target for syndromes of increased vascular permeability
    immunologyinfectious 
    selective inhibitors of pro-PHBP activation would be useful tools to treat septic shock
    ANIMAL & CELL MODELS