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FLASH GENE
Symbol H3F3B contributors: mct - updated : 13-11-2014
HGNC name H3 histone, family 3B (H3.3B)
HGNC id 4765
Location 17q25      Physical location : 73.772.516 - 73.775.860
Synonym name H3 histone, family 3A
Synonym symbol(s) H3.3B, H3F3A, H3F3, H3.3A
DNA
TYPE functioning gene
STRUCTURE 3.35 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 polyA site 2753 - 136 - 2003 12909349
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus  highly
Respiratorylung   highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
conjugated Other
mono polymer heteromer , octamer
HOMOLOGY
interspecies homolog to murine H3f3b
homolog to C.elegans f45e1.6
intraspecies paralog to similar to H3F3A
Homologene
FAMILY
  • histone H3 family
    • CATEGORY structural protein , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • replacement histone protein, independent from the cell cycle
  • playing a role in the compaction of DNA into nucleosomes
  • H3F3A, H3F3B has multiple functions in distinct genomic locations that are not always correlated with an “active” chromatin state
  • H3F3A, H3F3B are not required for active transcription but instead may be necessary for establishing a chromatin landscape allowing for proper gene expression upon differentiation
  • H3F3A, H3F3B are a crucial maternal factor for oocyte reprogramming, providing a practical model to directly dissect the oocyte for its reprogramming capacity
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of nucleosomes
    • INTERACTION
    DNA approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A, H2B, H3, H4
  • interacting with DAXX (DAXX was stably associated with the H3F3A complex)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS