basic FUNCTION
| replacement histone, independent of the cell cycle |
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playing a role in the compaction of DNA into nucleosomes |
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H3F3A serine 10 phosphorylation is necessary for the dissociation of CBX1, CBX3, CBX5 from chromatin in M phase |
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H3F3A, H3F3B are incorporated in chromatin after disruption of nucleosomes mediated by transcription elongation |
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with H2AFZ, affect nucleosome positioning, either creating new positions or altering the relative occupancy of the existing nucleosome position space |
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incorporated into chromatin in a replication-independent manner |
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H3F3A, H3F3B has multiple functions in distinct genomic locations that are not always correlated with an “active” chromatin state |
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H3F3A, H3F3B are not required for active transcription but instead may be necessary for establishing a chromatin landscape allowing for proper gene expression upon differentiation |
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H3F3A, H3F3B are a crucial maternal factor for oocyte reprogramming, providing a practical model to directly dissect the oocyte for its reprogramming capacity |