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FLASH GENE
Symbol H3F3A contributors: mct - updated : 09-06-2014
HGNC name H3 histone, family 3A
HGNC id 4764
Location 1q42.12      Physical location : 226.250.420 - 226.259.702
Synonym name histone H3.3
Synonym symbol(s) H3F3, H3.3A, HIST3, MGC87782, MGC87783, H3F3B
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text cluster 3 genes
STRUCTURE 9.28 kb     4 Exon(s)    20 Copie(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D1S271E - D1S479 /H3F3A - D1S439 - qter
Authors Lin (97)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- polyA site 1300 - 136 - 1987 3031613
class c
4 polyA site 1117 - 136 - 2002 11751582
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
conjugated Other
mono polymer heteromer , octamer
HOMOLOGY
interspecies homolog to murine H3f3a
Homologene
FAMILY
  • H3 histone family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • replacement histone, independent of the cell cycle
  • playing a role in the compaction of DNA into nucleosomes
  • H3F3A serine 10 phosphorylation is necessary for the dissociation of CBX1, CBX3, CBX5 from chromatin in M phase
  • H3F3A, H3F3B are incorporated in chromatin after disruption of nucleosomes mediated by transcription elongation
  • with H2AFZ, affect nucleosome positioning, either creating new positions or altering the relative occupancy of the existing nucleosome position space
  • incorporated into chromatin in a replication-independent manner
  • H3F3A, H3F3B has multiple functions in distinct genomic locations that are not always correlated with an “active” chromatin state
  • H3F3A, H3F3B are not required for active transcription but instead may be necessary for establishing a chromatin landscape allowing for proper gene expression upon differentiation
  • H3F3A, H3F3B are a crucial maternal factor for oocyte reprogramming, providing a practical model to directly dissect the oocyte for its reprogramming capacity
  • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core histone H2A/H3B/H3/H4
  • INTERACTION
    DNA approximatively 0.146 kb
    RNA
    small molecule
    protein
  • H2A, H2B, H3H4
  • interacting with ATRX (ATRX interacts with H3F3A in maintaining telomere structural integrity in pluripotent embryonic stem cells)
  • interacting with DAXX (DAXX was stably associated with the H3F3A complex)
  • cell & other
    REGULATION
    Other phosphorylated by Aurora B (AURBK), survivin dependent
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in pediatric diffuse intrinsic pontine glioma (DIPG)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS