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FLASH GENE
Symbol H2AFY contributors: - updated : 07-04-2006
HGNC name H2A histone family, member Y
HGNC id 4740
Location 5q31.3-q32      Physical location : 134.670.070 - 134.735.577
Synonym symbol(s) H2AF12M, H2AFJ, MACROH2A1.2, H2A1M
DNA
TYPE functioning gene
STRUCTURE 64.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
Map cen - D5S471 - D5S622 - D5S467 - D5S649 - IL5 - D5S666 - H2AFY - TGFBI - D5S393 - qter
Authors GeneMap (98)
Physical map
CDKL3 5q31 cyclin-dependent kinase-like 3 UBE2B 5q31 ubiquitin-conjugating enzyme E2B (RAD6 homolog) MGC13017 5q31.2 similar to RIKEN cDNA A430101B06 gene LOC391833 5 similar to 40S ribosomal protein S10 PHF15 5q31.2 PHD finger protein 15 SARA2 5q31.1 SAR1a gene homolog 2 (S. cerevisiae) SEC24A 5 SEC24 related gene family, member A (S. cerevisiae) CAMLG 5q23 calcium modulating ligand DDX46 5q31.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 FLJ37562 5q31.2 hypothetical protein FLJ37562 FLJ22625 5q31.2 hypothetical protein FLJ22625 DCOHM 5q31.2 hypothetical protein FLJ22625 CATSPER3 5q31.2 cation channel, sperm associated 3 PITX1 5q31 paired-like homeodomain transcription factor 1 LOC389328 5 LOC389328 LOC389329 5 LOC389329 H2AFY 5q31.3-q32 H2A histone family, member Y DCNP1 5q31.2 dendritic cell nuclear protein 1 LOC345607 5q31.2 similar to FLJ00292 protein NEUROG1 5q23-q31 neurogenin 1 CXCL14 5q31 chemokine (C-X-C motif) ligand 14 LOC389330 5 LOC389330 LOC389331 5 LOC389331 LOC153328 5q31.2 similar to CG4995 gene product IL9 5q31.1 interleukin 9 FBXL3B 5q31 F-box and leucine-rich repeat protein 3B LECT2 5q31.1-q32 leukocyte cell-derived chemotaxin 2 TGFBI 5q31.1 transforming growth factor, beta-induced, 68kDa DAMS 5q31.1 SMAD in the antisense orientation MADH5 5q31.1 MAD, mothers against decapentaplegic homolog 5 (Drosophila) LOC389332 5 hypothetical gene supported by BC048329 TRPC7 5q31.2 transient receptor potential cation channel, subfamily C, member 7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1899 39.4 372 - Lee, Hernandez-Munoz
- splicing 1890 39 369 - Lee, Hernandez-Munoz
- - 1923 39.4 371 - Hernandez-Munoz
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemprostate  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • DUF27 domain,
  • small stretch of basic AA
  • a putative leucine zipper motif
  • highly alpha-helical C-terminus confering an asymmetric conformation to nucleosomes
    • HOMOLOGY
    interspecies homolog to murine H2afy
    intraspecies homolog to H2A
    Homologene
    FAMILY H2A histone family, DUF27 family
    CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,nucleosome
    intracellular,nucleus,chromatin/chromosome,euchromosome
    basic FUNCTION
  • involved in compaction of DNA into nucleosome
  • actively involved in stable X inactivation
    • CELLULAR PROCESS nucleotide, chromatin organization, remodeling
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component core histone H2A/H3B/H3/H4
    INTERACTION
    DNA approximatively 0.146 kb
    RNA
    small molecule
    protein H2A, H2B, H3, H4
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS