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Symbol H19-ICR contributors: mct - updated : 08-07-2015
HGNC name H19/IGF2 imprinting control region
HGNC id
Location 11p15.5      Physical location : -
Synonym symbol(s) IC1, ICR1, H19-DMD, ICR1-DMR
DNA
TYPE locus Control Region
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains composed by repetitive modules containing six to seven CTCF target sequences, and CTCF binding is required to maintain the maternal IC1 hypomethylated during early embryogenesis
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • is a chromatin insulator
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • its function is mediated by interaction with the zinc-finger protein CTCF that by inducing allele-specific higher-order chromatin conformations prevents the activation of IGF2 promoters by downstream enhancers on the maternal chromosome
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS