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FLASH GENE
Symbol GZMK contributors: mct - updated : 11-05-2012
HGNC name granzyme K (granzyme 3; tryptase II)
HGNC id 4711
Location 5q11.2      Physical location : 54.320.106 - 54.329.960
Synonym name
  • tryptase 2
  • cytotoxic T-lymphocyte-associated granule serine protease 5
  • granzyme K (serine protease, granzyme 3; tryptase II)
  • fragmentin-3
  • NK-tryptase-2
  • granzyme-3
  • Synonym symbol(s) TRYP2, PRSS, GTLA5, GRAK, NK-TRYP-2
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    STRUCTURE 9.85 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29 PPAP2A 5q11 phosphatidic acid phosphatase type 2A LOC379013  ring finger protein 138 pseudogene LOC391785 5 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) FLJ90709 5q11.2 hypothetical protein FLJ90709 DDX4 5q11.2-q12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 LOC391786 5 similar to heterogeneous nuclear ribonucleoprotein H CRL3 5q11.2 gp130-like monocyte receptor IL6ST 5q11.1-q11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) FLJ11795 5q11.2 hypothetical protein FLJ11795 LOC345645 5q11.2 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC347593 5q11.2 60S ribosomal protein L26 pseudogene MAP3K1 5q11.2 mitogen-activated protein kinase kinase kinase 1 MGC33648 5q11.2 hypothetical protein MGC33648 FLJ35954 5q11.2 hypothetical protein FLJ35954 DKFZp761C169 5q11.2 vasculin LOC133374 5q11.2 similar to hypothetical protein FLJ10534
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1074 25.8 264 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immunenatural killer Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte tryptase
  • despite a more restricted cellular expression pattern, GzmK seems to participate in immune responses against several viruses
  • directly processes BID to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
  • serine protease stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells
  • cleaved the microtubule network protein beta-tubulin after two distinct Arg residues, and potentially displays a unique function by cleaving its own specific substrates
  • may exert a critical role in NK cell-mediated tumor clearance
  • key component of T-killer (Tc) cells believed to mediate pro-apoptotic activities
  • extracellular GZMK is capable of activating F2R and inducing fibroblast cytokine secretion and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hydrolyzes the nucleosome assembly protein SET in its recombinant and native forms or in intact cells
  • TP53 associates with granzyme K and is a physiological substrate of granzyme K (TP53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS