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FLASH GENE
Symbol GZMH contributors: - updated : 17-03-2006
HGNC name granzyme H (cathepsin G-like 2, protein h-CCPX)
HGNC id 4710
Location 14q11.2      Physical location : 25.075.692 - 25.078.864
Genatlas name related to murine granzyme C
Synonym name
  • cytotoxin serine protease-C
  • cytotoxic T-lymphocyte-associated serine esterase 1
  • Synonym symbol(s) CGL-2, CTLA2, CTSGL2, CCPX, CSP-C, CTLA1
    EC.number 3.4.21.-
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, tail to tail
    text
  • clustered with cathepsin G and CTSGL1
  • STRUCTURE 3.00 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    TGM1 14q11.2 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) RABGGTA 14q11.2 Rab geranylgeranyltransferase, alpha subunit DHRS1 14q11.2 dehydrogenase/reductase (SDR family) member 1 C14orf21 14q11.2 chromosome 14 open reading frame 21 CIDEB 14q11.2 cell death-inducing DFFA-like effector b LTB4R2 14q11.2-q12 leukotriene B4 receptor 2 LTB4R 14q11.2-q12 leukotriene B4 receptor ADCY4 14q11.2 adenylate cyclase 4 RIPK3 14q11.2 receptor-interacting serine-threonine kinase 3 NFATC4 14q11.2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 KIAA1305 14q11.2 KIAA1305 HCDI CMA1 14q11.2 chymase 1, mast cell CTSG 14q11.2 cathepsin G GZMH 14q11.2 granzyme H (cathepsin G-like 2, protein h-CCPX) GZMB 14q11.2 granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) STXBP6 14q11.2 syntaxin binding protein 6 (amisyn)
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon lowly
    Urinarykidney   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/HematopoieticNK cell
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal peptide
  • a peptidase S1 domain
  • three sites of glycosylation
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Gzmg
    ortholog to rattus Rnkp7
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text
  • cytoplasmic granules of cytolytic T-lymphocytes
  • basic FUNCTION
  • may be necessary for target cell lysis in cell-mediated immune responses
  • involved in cytolysis
  • acting as a serine-type endopeptidase
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS