Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GZMA contributors: mct/npt - updated : 21-06-2017
HGNC name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HGNC id 4708
Location 5q11.2      Physical location : 54.398.473 - 54.406.079
Synonym name
  • Hanuka factor,lymphocyte tryptase 1
  • CTL tryptase
  • fragmentin-1
  • granzyme-1
  • Synonym symbol(s) CTLA3, HFSP, HF
    EC.number 3.4.21.78
    DNA
    TYPE functioning gene
    STRUCTURE 7.59 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ITGA1 - LARS - SKIV2L2 - IL6ST - KFS2 - MSH3 - qter
    Authors Peterson (99)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 913 28.8 262 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   predominantly
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 26 aa signal peptide
  • a peptidase S1 domain
  • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to rattus Gzma (70.5 pc)
    homolog to murine Gzma (68.9 pc)
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • immunological synapse
  • basic FUNCTION
  • being necessary for target cell lysis in cell-mediated immune responses
  • producing cleavage after Lys or Arg
  • may be involved in apoptosis
  • acting as a lymphocyte tryptase
  • acting as a serine protease
  • critical role for GZMA and GZMB in dictating immunogenicity by influencing the mode of tumor cell death, indicating that granzymes contribute to the efficient generation of immune effector pathways in addition to their well-known role in apoptosis induction
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide-linked homodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS