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FLASH GENE
Symbol GZMA contributors: mct/npt - updated : 21-06-2017
HGNC name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HGNC id 4708
Location 5q11.2      Physical location : 54.398.473 - 54.406.079
Synonym name
  • Hanuka factor,lymphocyte tryptase 1
  • CTL tryptase
  • fragmentin-1
  • granzyme-1
  • Synonym symbol(s) CTLA3, HFSP, HF
    EC.number 3.4.21.78
    DNA
    TYPE functioning gene
    STRUCTURE 7.59 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ITGA1 - LARS - SKIV2L2 - IL6ST - KFS2 - MSH3 - qter
    Authors Peterson (99)
    Physical map
    PELO 5q11.2 pelota homolog (Drosophila) ITGA1 5p15-p11 integrin, alpha 1 ITGA2 5q23-q31 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) MOCS2 5q11 molybdenum cofactor synthesis 2 LOC391781 5 similar to ribosomal protein L13a; 60S ribosomal protein L13a; 23 kD highly basic protein LOC391782 5 similar to ribosomal protein S19; 40S ribosomal protein S19 FST 5p11.2 follistatin NDUFS4 5q11.1 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) ASSP9 5q11-q12 argininosuccinate synthetase pseudogene 9 FLJ20051 HSPB3 5q11.2 heat shock 27kDa protein 3 SNAG1 5q11.2 sorting nexin associated golgi protein 1 LOC389290 5 LOC389290 LOC391783 5 similar to membrane-spanning proteoglycan NG2 LOC391784 5 similar to CG12279-PA LOC153134 5q11.2 hypothetical LOC153134 ESM1 5q11.2 endothelial cell-specific molecule 1 GZMK 5q11-q12 granzyme K (serine protease, granzyme 3; tryptase II) GZMA 5q11-q12 granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) FLJ37927 5q11.2 CDC20-like protein LOC345643 5q11.2 similar to geminin UNG2 5p15.2-p13.1 uracil-DNA glycosylase 2 DHX29 5q11.2 DEAH (Asp-Glu-Ala-His) box polypeptide 29 PPAP2A 5q11 phosphatidic acid phosphatase type 2A LOC379013  ring finger protein 138 pseudogene LOC391785 5 similar to Adenylate kinase isoenzyme 4, mitochondrial (ATP-AMP transphosphorylase) FLJ90709 5q11.2 hypothetical protein FLJ90709 DDX4 5q11.2-q12 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 LOC391786 5 similar to heterogeneous nuclear ribonucleoprotein H CRL3 5q11.2 gp130-like monocyte receptor IL6ST 5q11.1-q11.2 interleukin 6 signal transducer (gp130, oncostatin M receptor) FLJ11795 5q11.2 hypothetical protein FLJ11795 LOC345645 5q11.2 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC347593 5q11.2 60S ribosomal protein L26 pseudogene MAP3K1 5q11.2 mitogen-activated protein kinase kinase kinase 1 MGC33648 5q11.2 hypothetical protein MGC33648 FLJ35954 5q11.2 hypothetical protein FLJ35954 DKFZp761C169 5q11.2 vasculin LOC133374 5q11.2 similar to hypothetical protein FLJ10534 LOC391787 5 similar to sal-like 4 LOC345651 5q12.1 similar to RIKEN cDNA 4732495G21 gene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 913 28.8 262 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective   predominantly
    cell lineage
    cell lines
    fluid/secretion moderately in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 26 aa signal peptide
  • a peptidase S1 domain
  • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to rattus Gzma (70.5 pc)
    homolog to murine Gzma (68.9 pc)
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • immunological synapse
  • basic FUNCTION
  • being necessary for target cell lysis in cell-mediated immune responses
  • producing cleavage after Lys or Arg
  • may be involved in apoptosis
  • acting as a lymphocyte tryptase
  • acting as a serine protease
  • critical role for GZMA and GZMB in dictating immunogenicity by influencing the mode of tumor cell death, indicating that granzymes contribute to the efficient generation of immune effector pathways in addition to their well-known role in apoptosis induction
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide-linked homodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS