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FLASH GENE
Symbol GYS2 contributors: mct - updated : 16-05-2009
HGNC name glycogen synthase 2 (liver)
HGNC id 4707
Corresponding disease
GSD0 glycogen storage disease, type 0
Location 12p12.1      Physical location : 21.689.124 - 21.757.781
Synonym name glycogen (starch) synthase, liver
Synonym symbol(s) GYSL
EC.number 2.4.1.11
DNA
TYPE functioning gene
STRUCTURE 68.66 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 3132 80.9 703 - 1994 8188280
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated PhosphoP
HOMOLOGY
intraspecies paralog to GYS1
Homologene
FAMILY
  • mammalian/fungal glycogen synthase family
  • glycosyltransferase 3 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • the rate limiting enzyme of the insulin-induced glycogenesis, transferring glucose units from UDP-Glc to a glycogen primer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
  • complexing with GYG2 and TRIM7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct target gene of PPARalpha (PPARA), PPARbeta/delta and PPARgamma (PPARG) (Mandard (2007)
  • cell & other
    REGULATION
    activated by stimulated (dephosphorylated) by insulin
    inhibited by phosphorylated by epinephrine or glucagon
    Other regulated by CLOCK (regulates the circadian rhythms of hepatic glycogen synthesis through transcriptional activation of GYS2)
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD0
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS