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FLASH GENE
Symbol GYPA contributors: - updated : 11-09-2003
HGNC name glycophorin A (includes MN blood group)
HGNC id 4702
Corresponding disease
MNS MNS blood group
Location 4q28.2-31.1      Physical location : 145.030.456 - 145.061.904
Synonym name glycophorin A,including the stone (Sta)
Synonym symbol(s) GLPA
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map 5' - GYPA - GYPB - GYPE - 3'
Authors Onda (95)
Physical map
LOC389225 4 LOC389225 LOC389226 4 similar to ring finger protein 130; g1-related zinc finger protein RNF150 4q31.1 ring finger protein 150 LOC389227 4 LOC389227 ZNF330 4q31.1-q31.2 LOC389227 LOC389228 4 similar to GRIK2 protein IL15 4q31 interleukin 15 INPP4B 4q31.11 inositol polyphosphate-4-phosphatase, type II, 105kDa USP38 4q31.1 ubiquitin specific protease 38 GAB1 4q31.4-q13.5 GRB2-associated binding protein 1 SMARCA5 4q31.1-q31.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 LOC389229 4 similar to Beta-glucuronidase precursor (Beta-G1) LOC166752 4q31.1 similar to embryonic blastocoelar extracellular matrix protein precursor GYPE 4q31 glycophorin E LOC152891 4q31.1 similar to WW45 protein GYPB 4q28-q31 glycophorin B (includes Ss blood group) GYPA 4q28.2-31.1 glycophorin A (includes MN blood group) LOC391703 4 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) HHIP 4q28-q32 hedgehog interacting protein LOC345041 4q31.21 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) APC10 4q31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) ABCE1 4q31 ATP-binding cassette, sub-family E (OABP), member 1 HSHIN1 4q31.21 HIV-1 induced protein HIN-1 LOC389230 4 LOC389230 LOC152905 4q31.21 similar to Reticulon protein 3 (Neuroendocrine-specific protein-like 2) (NSP-like protein II) (NSPLII) FLJ13262 4q31.21 hypothetical protein FLJ13262 MADH1 4q28 MAD, mothers against decapentaplegic homolog 1 (Drosophila) DKFZP586M0622 LOC345045 4q31.21 similar to nuclear receptor coactivator 4; RET-activating gene ELE1 MMAA LOC152485 4q31.21 hypothetical protein LOC152485 LSM6 4q31.21 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) LOC345051 4q31.21 similar to MGC53273 protein DKFZP566M114 4q31.21 hypothetical protein DKFZp566M114 POU4F2 4q31.2 POU domain, class 4, transcription factor 2 NYD-SP14 4q31.21 NYD-SP14 protein
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerthrocyte
Blood/Hematopoieticerythroid
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spleen,eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
carbohydrate rich sialoglycoprotein
variant antigen associated either with a splicing mutation of GYPA or a hybrid formation between GYPA and GYPB or between GYPA and GYPE
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY glycophorin A family
CATEGORY antigen
SUBCELLULAR LOCALIZATION     plasma membrane
text erythrocytes membrane
basic FUNCTION having MN blood group receptors and also binding influenza virus
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component major protein constituent of erythrocyte membrane
INTERACTION
DNA
RNA
small molecule
protein
cell & other
REGULATION
ASSOCIATED DISORDERS
corresponding disease(s) MNS
related resource Blood Group Antigen Mutation Database
Susceptibility
Variant & Polymorphism other
  • stone (Sta) variant antigen associated either with a splicing mutation of GPA or a hybrid formation between GYPA and GYPB or between GYPA and GPYE
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS