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FLASH GENE
Symbol GXYLT1 contributors: SGE/npt - updated : 15-04-2010
HGNC name glucoside xylosyltransferase 1
HGNC id 27482
Location 12q12      Physical location : 42.475.649 - 42.538.673
Synonym name
  • glycosyltransferase 8 domain containing 3
  • LOC283464 protein
  • Synonym symbol(s) FLJ43151, GLT8D3
    EC.number 2.4.1.-, 2.4.2.n2
    DNA
    TYPE functioning gene
    STRUCTURE 63.03 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 7416 - 409 - Sethi (2010)
    8 - 7509 - 440 - Sethi (2010)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     neuroendocrinepituitary   
    Hearing/Equilibriumear    
    Reproductivefemale systemplacenta   
    Respiratoryrespiratory tractlarynx   
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short N-terminal cytoplasmic domain
  • a transmembrane domain
  • a stem region
  • a large glycosyltransferase domain containing the conserved DxD motif
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Glt8d3 (88.1pc)
    homolog to rattus Glt8d3 (86.7pc)
    Homologene
    FAMILY
  • glycosyltransferase 8 family (GT8 family)
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type II membrane protein
    basic FUNCTION
  • elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose
  • GXYLT1 and GXYLT2 (glucoside-xylosyltransferase 1/2), are able to transfer the first alpha1,3-linked xylose to O-glucosylated mammalian Notch EGF repeats
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS