Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GULP1 contributors: mct/npt/shn - updated : 14-06-2017
HGNC name GULP, engulfment adaptor PTB domain containing 1
HGNC id 18649
Location 2q32.1      Physical location : 189.157.389 - 189.460.650
Synonym name
  • PTB domain adapter protein CED-6
  • PTB domain adaptor protein CED-6
  • PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog
  • engulfment adapter protein
  • Synonym symbol(s) GULP, CED-6, FLJ31156, CED6
    DNA
    TYPE functioning gene
    STRUCTURE 304.26 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D2S1361 - D2S152 - GULP1 - D2S2262 - D2S118 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3450 - 304 - 2013 23167255
    13 - 3523 - 291 - 2013 23167255
    9 - 3203 - 201 - 2013 23167255
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage
    cell lineage
    cell lines cancer cells
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a phosphotyrosine-binding (PTB) domain
  • a potential Src-homology domain 3 (SH3) binding sites
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gulp1, Mus musculus
    ortholog to Gulp1, Rattus norvegicus
    ortholog to GULP1, Pan troglodytes
    ortholog to gulp1, Danio rerio
    Homologene
    FAMILY
  • ced-6 family
  • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • mediating the phagocytosis of apoptotic cells
  • adaptor protein required for efficient engulfment of apoptotic cells by phagocytes
  • playing an important role in stabilin-2-mediated phagocytosis
  • required for actin reorganization around the apoptotic cell corpse
  • GULP1 is a modifier of cellular ARF6-GTP through regulation of ACAP1
  • functions as an adaptor protein for stabilin-1-mediated phagocytosis
  • is a novel APP/(APP C-terminal domain-interacting protein that influences APP processing and Abeta production
  • because GULP1 expression positively regulates TGFB1 signaling leading to growth inhibition, this may represent an attractive target to achieve TGFB1 responsiveness in ovarian cells
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CED-1 and CD91/low density lipoprotein receptor-related protein,LRP
  • role for GULP1 as a positive regulator of ARF6
  • SCARB1 binds to engulfment adapter protein (GULP1) using the C-terminal intracellular domain, and PS-recognizing SCARB1 activates associated GULP1
  • is able to specifically interact with the NPxF/Y motif of STAB1 cytoplasmic region
  • GULP1-APP interaction is mediated by the NPTY motif of APP and the GULP1 PTB (phosphotyrosine-binding) domain
  • is an adapter to LRP1 and mediates TGFB1 signaling in signaling-competent early endosomes
  • GULP1 mediates LRP1 transactivation
  • PEAR1 associates with GULP1, the mammalian homologue of Ced-6, an adaptor protein required for phagocytosis mediated by the nematode engulfment receptor Ced-1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS