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FLASH GENE

Symbol

GULP1

contributors: mct/npt/shn - updated : 14-06-2017

HGNC name	GULP, engulfment adaptor PTB domain containing 1
HGNC id	18649

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q32.1      Physical location : 189.157.389 - 189.460.650
Synonym name	PTB domain adapter protein CED-6
	PTB domain adaptor protein CED-6
	PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog
	engulfment adapter protein
Synonym symbol(s)	GULP, CED-6, FLJ31156, CED6

DNA

TYPE	functioning gene
STRUCTURE	304.26 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D2S1361 - D2S152 - GULP1 - D2S2262 - D2S118 - qter

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016315 12 - 3450 NP_057399 - 304 - 2013 23167255 NM_001252668 13 - 3523 NP_001239597 - 291 - 2013 23167255 NM_001252669 9 - 3203 NP_001239598 - 201 - 2013 23167255

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta     highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage
cell lines	cancer cells
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a phosphotyrosine-binding (PTB) domain
	a potential Src-homology domain 3 (SH3) binding sites

mono polymer

homomer , dimer

HOMOLOGY

interspecies	ortholog to Gulp1, Mus musculus
	ortholog to Gulp1, Rattus norvegicus
	ortholog to GULP1, Pan troglodytes
	ortholog to gulp1, Danio rerio

Homologene

FAMILY

ced-6 family

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	mediating the phagocytosis of apoptotic cells
	adaptor protein required for efficient engulfment of apoptotic cells by phagocytes
	playing an important role in stabilin-2-mediated phagocytosis
	required for actin reorganization around the apoptotic cell corpse
	GULP1 is a modifier of cellular ARF6-GTP through regulation of ACAP1
	functions as an adaptor protein for stabilin-1-mediated phagocytosis
	is a novel APP/(APP C-terminal domain-interacting protein that influences APP processing and Abeta production
	because GULP1 expression positively regulates TGFB1 signaling leading to growth inhibition, this may represent an attractive target to achieve TGFB1 responsiveness in ovarian cells

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	CED-1 and CD91/low density lipoprotein receptor-related protein,LRP
	role for GULP1 as a positive regulator of ARF6
	SCARB1 binds to engulfment adapter protein (GULP1) using the C-terminal intracellular domain, and PS-recognizing SCARB1 activates associated GULP1
	is able to specifically interact with the NPxF/Y motif of STAB1 cytoplasmic region
	GULP1-APP interaction is mediated by the NPTY motif of APP and the GULP1 PTB (phosphotyrosine-binding) domain
	is an adapter to LRP1 and mediates TGFB1 signaling in signaling-competent early endosomes
	GULP1 mediates LRP1 transactivation
	PEAR1 associates with GULP1, the mammalian homologue of Ced-6, an adaptor protein required for phagocytosis mediated by the nematode engulfment receptor Ced-1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS