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FLASH GENE

Symbol

GUCY1A3

contributors: mct/npt - updated : 29-03-2014

HGNC name	guanylate cyclase 1, soluble, alpha 3
HGNC id	4685

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	MYMYA moyamoya and achalasia
Location	4q32.1      Physical location : 156.587.861 - 156.658.212
Synonym name	GC-S-alpha-1
	GCS-alpha-3
	soluble guanylate cyclase large subunit
Synonym symbol(s)	GCSA3, GUC1A3, GUCA3, GUCY1A1, sGCalpha1
EC.number	4.6.1.2

DNA

TYPE	functioning gene
STRUCTURE	70.35 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000856 11 - 9454 NP_000847 77.4 690 - 2011 20964618 NM_001130682 10 - 9360 NP_001124154 - 690 - 2011 20964618 NM_001130687 9 - 2690 NP_001124159 - 624 - 2011 20964618 NM_001256449 10 - 9291 NP_001243378 - 690 - 2011 20964618 NM_001130683 10 - 9328 NP_001124155 - 690 - 2011 20964618 NM_001130685 10 - 9149 NP_001124157 - 455 - 2011 20964618 NM_001130684 9 - 9300 NP_001124156 - 690 - 2011 20964618

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Rattus norvegicus Nervous brain       highly Reproductive male system prostate     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Muscular smooth vessel     Rattus norvegicus Muscular striatum skeletal     Rattus norvegicus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

adenylyl cyclase class-4/guanylyl cyclase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

extracellular

basic FUNCTION	catalyzing conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs
	crucial role of the NO/GUCY1A3/GUCY1B3/cGMP pathway in modulating lymphatic vessel function
	although GUCY1A3 importantly regulates cardiac contractility, it is not required for cardioprotection by ischemic preconditioning (IPC)
	is a novel androgen-regulated gene essential for prostate cancer cell proliferation
	is the mammalian endogenous nitric oxide (NO) receptor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

crucial role of the NO/GUCY1A3/GUCY1B3/cGMP pathway in modulating lymphatic vessel function

a component

heterodimeric protein consisting of an alpha subunit, such as alpha-1 (GUCY1A3), and a beta subunit, typically beta-1 (GUCY1B3)

INTERACTION

DNA

RNA

small molecule

protein	can inhibit the transcriptional activity of TP53 in prostate cancer cells independent of either classical mediators of NO signaling
	producing the cGMP second messenger in photoreceptors, GUCY1A3 requires RHO for intracellular stability and outer segment delivery

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MYMYA

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in gliomas tumoral     --over   in prostate tumors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS