Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GUCA1C contributors: npt/ - updated : 22-12-2007
HGNC name guanylate cyclase activator 1C
HGNC id 4680
Location 3q13.1      Physical location : 108.626.641 - 108.672.677
Synonym name guanylyl cyclase-activating protein 3
Synonym symbol(s) GCAP3, MGC120158, MGC120159
DNA
TYPE functioning gene
STRUCTURE 45.97 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 860 23.7 209 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four EF-hand calcium-binding domains
  • a putative N myristoylation site at gly2
  • HOMOLOGY
    interspecies homolog to C.elegans K03E6.3
    Homologene
    FAMILY
  • calmodulin superfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • calcium sensitive guanylate cyclase activator (stimulation when low Ca2+ concentration and inhibition when elevated)
  • stimulating cGMP formation by guanylate cyclases in retina (GC1and GC2)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+ (three ions)
  • protein
    cell & other
    REGULATION
    activated by the decrease of Ca2+ ions
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS