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FLASH GENE
Symbol GTF3C3 contributors: KTN - updated : 05-12-2007
HGNC name general transcription factor IIIC, polypeptide 3, 102kDa
HGNC id 4666
Location 2q33.1      Physical location : 197.629.104 - 197.664.425
Synonym symbol(s) TFIIIC102,TFIIIC2-102, TFIIICgamma
DNA
TYPE functioning gene
STRUCTURE 35.00 kb     18 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC389067 2 LOC389067 LOC343981 2q33.1 similar to Glutamine synthetase (Glutamate--ammonia ligase) LOC391470 2 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) SLC39A10 2q33.1 solute carrier family 39 (zinc transporter), member 10 DNAH7 2q33-1 dynein, axonemal, heavy polypeptide 7 STK17B 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) NEDL2 2q33.1 serine/threonine kinase 17b (apoptosis-inducing) FLJ39660 2q33.1 hypothetical protein FLJ39660 LOC200624 2q33.1 hypothetical LOC200624 DKFZp434P055 2q33.1 hypothetical protein DKFZp434P055 GTF3C3 2q33.1 general transcription factor IIIC, polypeptide 3, 102kDa LOC389068 2 similar to ISPD3024 FLJ12377 LOC91526 2q33.1 hypothetical protein DKFZp434D2328 LOC391471 2 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 SF3B1 2p23.3-q34 splicing factor 3b, subunit 1, 155kDa FLJ13448 2q33.1 hypothetical protein FLJ13448 HSPD1 2q33.1 heat shock 60kDa protein 1 (chaperonin) HSPE1 2q33.1 heat shock 10kDa protein 1 (chaperonin 10) PREI3 2q33.1 preimplantation protein 3 C2orf11 2q33.1 chromosome 2 open reading frame 11 LOC92935 2q33.1 hypothetical protein BC009115 BOLL 2q33.1 bol, boule-like (Drosophila) PLCL1 2q33 phospholipase C-like 1 SATB2 2q32-q33 SATB family member 2 FLJ32063 2q33.1 hypothetical protein FLJ32063 LOC389069 2 similar to selenophosphate synthetase 1 LOC389070 2 LOC389070 FLJ38973 2q33.1 hypothetical protein FLJ38973 FLJ37953 2q33.1 hypothetical protein FLJ37953 FLJ22555 2q33.1 hypothetical protein FLJ22555
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 2958 101 886 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 mouthtongue  moderately
Hearing/Equilibriumear   moderately
Lymphoid/Immunelymph node   moderately
 thymus   moderately
Nervousbrain   moderately
 nerve   highly
Reproductivefemale systembreastmammary gland moderately
 male systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
 respiratory tractlarynx  predominantly
Urinarybladder   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • eleven tetratricopeptide repeats (TPR)
  • secondary structure
  • helix-loop-helix domain
  • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to dog GTF3C3 (96.3 pc)
    homolog to rattus Gtf3c3 (93.8 pc)
    homolog to murine Gtf3c3 (93.9 pc)
    homolog to chicken GTF3C3 (89.3 pc)
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in recruitement of both TFIIIB and RNA polymerase III
  • involved in RNA polymerase III-mediated transcription
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text
  • 5S class rRNA transcription
  • tRNA transcription from RNA polymerase III promoter
  • PATHWAY
    metabolism
    signaling
    a component
  • part of the TFIIIC subcomplex TFIIIC2, consisting of five subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4 and GTF3C5
  • INTERACTION
    DNA binding to virus-associated RNA promoters
    RNA binding to tRNA
    small molecule
    protein
  • interacting with TFIIIC63/GTF3C5
  • interacting with TFIIIB90/BRF1
  • interacting with TBP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS