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FLASH GENE
Symbol GTF3C2 contributors: KTN - updated : 04-12-2007
HGNC name general transcription factor IIIC, polypeptide 2, beta 110kDa
HGNC id 4665
Location 2p23.3      Physical location : 27.548.720 - 27.579.868
Synonym symbol(s) KIAA0011,TFIIIC-beta, TFIIIC110
DNA
TYPE functioning gene
STRUCTURE 31.00 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
MAPRE3 2p23.3-p23.1 microtubule-associated protein, RP/EB family, member 3 FLJ20254 2p23.3 hypothetical protein FLJ20254 FLJ21839 2p23.3 hypothetical protein FLJ21839 EMILIN1 2p23.3-p23.2 elastin microfibril interfacer 1 KHK 2p23.3-p23.2 ketohexokinase (fructokinase) CGREF1 2p23.3 cell growth regulator with EF hand domain 1 ABHD1 2p23.3 abhydrolase domain containing 1 PREB 2p23 prolactin regulatory element binding MGC44505 2p23.3 hypothetical protein MGC44505 LOC391360 2 similar to class II basic helix-loop-helix protein TCF23 SLC5A6 2p23 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 APR-3 2p23.3 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 CAD 2p22-p21 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase SLC30A3 2p23.3 solute carrier family 30 (zinc transporter), member 3 FLJ40417 2p23.3 gamma cysteine string protein RNF30 2p23.3 ring finger protein 30 UCN 2p23-p21 urocortin MPV17 2p23 MpV17 transgene, murine homolog, glomerulosclerosis GTF3C2 2p23.3 general transcription factor IIIC, polypeptide 2, beta 110kDa EIF2B4 2p23.3 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa SNX17 2p23-p22 sorting nexin 17 ZNF513 2p23.3 zinc finger protein 513 PPM1G 2p33.3 protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform NRBP 2p23 nuclear receptor binding protein KCP3 SLB 2p23.3 selective LIM binding factor, rat homolog FRCP1 GCKR 2p23.3-p23.2 glucokinase (hexokinase 4) regulatory protein DKFZp434G118 ZNF512 2p23 zinc finger protein 512 FLJ13646 2p23.3 hypothetical protein FLJ13646 XAB1 2p23.3 XPA binding protein 1 STAF65(gamma) 2pter-p25.1 SPTF-associated factor 65 gamma SLC4A1AP 2p23.3 solute carrier family 4 (anion exchanger), member 1, adaptor protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 splicing 3935 100 911 - -
19 splicing 3859 100 911 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  lowly
 liver   lowly
Endocrinepancreas   lowly
Lymphoid/Immunespleen   lowly
 thymus   lowly
Nervousbrain   lowly
Reproductivefemale systemovary  moderately
 male systemtestis  lowly
 male systemprostate  lowly
Respiratorylung   moderately
Urinarykidney   specific
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta, umbilial cord
PROTEIN
PHYSICAL PROPERTIES acid ,basic
STRUCTURE
motifs/domains
  • four WD 40 repeats (TRP-ASP domains)
  • stretches of acidic and basic regions
  • secondary structure
  • potential acidic and basic helices
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to dog GTF3C2 (93.7 pc)
    homolog to rattus Gtf3c2 (89.2 pc)
    homolog to murine Gtf3c2 (89 pc)
    Homologene
    FAMILY GTF3C family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs and adenoviral VA genes
  • initiating transcription complex assembly on tRNA
  • may play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, initiation
    PHYSIOLOGICAL PROCESS
    text
  • control of cell proliferation
  • PATHWAY
    metabolism
    signaling
    a component
  • beta subunit of the RNA polymerase III transcription factor TFIIIC
  • specific of TFIIIC2a
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS