Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GTF3C1 contributors: mct/ - updated : 22-03-2006
HGNC name general transcription factor IIIC, polypeptide 1, alpha 220kDa
HGNC id 4664
Location 16p12.1      Physical location : 27.471.934 - 27.561.251
Synonym name
  • general transcription factor IIIC, polypeptide 1 (alpha subunit)
  • TF3C-alpha
  • TFIIIC box B-binding subunit
  • Synonym symbol(s) TFIIIC, TFIIIC220, TFIIICalpha, DKFZp686A111
    DNA
    TYPE functioning gene
    STRUCTURE 89.32 kb     37 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390686 16 similar to ER degradation-enhancing alpha-mannosidase-like TNT 16p12.2 TNT protein LOC124199 16p12.2 similar to translation Elongation FacTor (eft-4) FLJ13798 16p12.2 hypothetical protein FLJ13798 NSE1 2p25.1 NSE1 IL4R 16p12.11-11.2 interleukin 4 receptor IL21R 16p11 interleukin 21 receptor GTF3C1 16p12.1-p11.2 general transcription factor IIIC, polypeptide 1, alpha 220kDa KIAA0556 16p12.2-p12.1 KIAA0556 protein MGC18079 16p12.1 hypothetical protein MGC18079 XPO6 16p12 exportin 6 LOC390687 16 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388228 16 similar to SH3-binding kinase LOC388229 16 similar to Group X secretory phospholipase A2 precursor (Phosphatidylcholine 2-acylhydrolase GX) (GX sPLA2) (sPLA2-X) EIF3S8 16p11.2 eukaryotic translation initiation factor 3, subunit 8, 110kDa LOC283890 16p12.1 similar to nuclear pore complex interacting protein LOC388230 16 similar to MGC9515 protein LOC388231 16 LOC388231 SULT1A1 16p12.1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 SULT1A2 16p12-p11.2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 LOC112869 16p12.1 hypothetical protein BC011981 P8 16p11.2 p8 protein (candidate of metastasis 1) IL27  interleukin 27 LOC388232 16 similar to apolipoprotein B48 receptor
    RNA
    TRANSCRIPTS type messenger
    text two isoforms GTF3C102 and GTF3C63
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    37 - 7124 - 2109 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunethymus   highly
    cell lineage
    cell lines
    fluid/secretion lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid ,basic
    STRUCTURE
    motifs/domains
  • containing acidic and basic region, tetratricopeptide repeat*
  • a TOR signaling motif that facilitates its association with MTOR
  • secondary structure
  • a helix-loop-helix domain
  • HOMOLOGY
    interspecies ortholog to rattus Rn11288
    Homologene
    FAMILY
  • TFIIIC subunit 1 family
  • GTF3C family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in recruitment of both GTF3B and RNA Pol3
  • component of TFIIIC initiating transcription complex assembly on tRNA and required for transcription of 5s rRNA and other stable nuclear and cytoplasmic RNAs
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • alpha subunit of transcription factor TFIIIC
  • INTERACTION
    DNA binding to B-box promoter elements
    RNA
    small molecule
    protein
  • interaction of MTOR with MAF1 and GTF3C1 in nuclei
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS