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FLASH GENE
Symbol GTF3A contributors: mct/npt - updated : 04-11-2009
HGNC name general transcription factor IIIA
HGNC id 4662
Location 13q12.2      Physical location : 27.998.680 - 28.009.846
Synonym name
  • transcription factor IIIA
  • factor A
  • Synonym symbol(s) TF3A, AP2, TFIIIA
    DNA
    TYPE functioning gene
    STRUCTURE 11.17 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1404 - 365 - Hanas (2002)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Lymphoid/Immunelymph node   highly
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    not specificadipocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • nine C2H2 zinc finger domains
  • a non-finger C-terminal tail with conserved transcription activation domain as well as conserved nuclear localization and nuclear export signals (Hanas 2002)
  • HOMOLOGY
    interspecies homolog to Xenopus
    homolog to C.elegans T08b2.11
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • required for initiation of transcription of 5s RNA
  • initiating transcription of the 5 s ribosomal RNA gene
  • maintaining the stability of transcription of other genes
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the internal control region (icr) of approximately 50 bases within the 5S RNA gene
    RNA binding to transcribed 5S RNAs
    small molecule metal binding,
  • Zn2+
  • protein
  • FT3A interacting protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS