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FLASH GENE
Symbol GTF2E1 contributors: mct - updated : 08-03-2016
HGNC name general transcription factor IIE, polypeptide 1, alpha 56kDa
HGNC id 4650
Location 3q13.33      Physical location : 120.461.557 - 120.501.915
Synonym symbol(s) TF2EA, TF2E1, FE, TFIIE-A
DNA
TYPE functioning gene
STRUCTURE 40.36 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3033 - 5 - 439 - 2015 25492609
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc finger motif, essential for its function, particularly in the transition from the transcription initiation to elongation and the conformational tuning of this domain for appropriate positioning of TFIIF, TFIIH, and polymerase II would be needed depending on the situation and timing
  • leucine repeat
  • three-winged helix (WH) motifs, with one in GTF2E1 and two in GTF2E2
  • secondary structure helix-turn-helix
    mono polymer heteromer , tetramer
    HOMOLOGY
    interspecies homolog to murine Gtf2e1
    homolog to C.elegans Zk550.4
    Homologene
    FAMILY TFIIE alpha subunit family
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in the regulation of transcription inhitiation
  • T2FH recruitment to initiation complex
  • stimulating the RNA polymerase II C terminal domain kinase and RNA dependent ATPase activities of TFIIH
  • has essential roles in both transcription initiation and promoter escape
  • CELLULAR PROCESS nucleotide, transcription, initiation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotetramer of two alpha and two beta chains
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • GTF2H1 is recruited to the transcription preinitiation complex through an interaction between its p62/Tfb1 subunit and the alpha-subunit of GTF2E1
  • GTF2E1 and TP53 share the binding region on GTF2H1
  • CDK7 thus acts through GTF2E1, GTF2E2 and SUPT5H to establish, and through CDK9 to relieve, barriers to elongation
  • GTF2E2 binds to the WH domain of GTF12E1 via its bHLH domain (basic region-helix-loop-helix motif, AAs 193240)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS