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FLASH GENE
Symbol GTF2A1L contributors: npt/ - updated : 02-04-2007
HGNC name general transcription factor IIA, 1-like
HGNC id 30727
Location 2p16.3      Physical location : 48.844.936 - 48.960.284
Synonym name
  • GTF2A1-like factor
  • TFIIA-alpha/beta-like factor
  • Synonym symbol(s) MGC26254, ALF, GTF2A1LF
    DNA
    TYPE functioning gene
    STRUCTURE 115.34 kb     8 Exon(s)
    regulatory sequence Promoter
    cytosine-phosphate-guanine/HTF
    text structure a unique CpG-specific methylation pattern at the ALF promoter precedes expression in pachytene spermatocytes
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1668 52.4 478 - Kim (2006)
    9 - 1656 - 453 - Kim (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatid
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • organized into four regions that are characterisitc of all TFIIA large subunits, including the conserved N and C terminal domains
  • conserved regions I and IV and acidic region III but a distinct region II
  • HOMOLOGY
    interspecies ortholog to murine Gtf2a1lf
    intraspecies paralog to TFIIA alpha/beta
    Homologene
    FAMILY
  • TFIIA subunit 1 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • testis specific transcription factor, that may function in spermatogenesis, especially in spermiogenesis
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    text transcription co-activator
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
  • binding in conjunction with GTF2A2 and TBP (the TATA-binding protein)
  • RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by multivalent zinc finger chromatin insulator protein CTCF
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    abnormal expression might be partial cause for infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS