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FLASH GENE
Symbol GSTZ1 contributors: npt/ - updated : 05-10-2005
HGNC name glutathione transferase zeta 1
HGNC id 4643
Location 14q24.3      Physical location : 77.787.229 - 77.797.939
Synonym name
  • S-(hydroxyalkyl)glutathione lyase
  • glutathione S-aryltransferase
  • glutathione transferase zeta 1 (maleylacetoacetate isomerase)
  • maleylacetoacetate isomerase
  • Synonym symbol(s) MAI, MAAI, GSTZ1-1, MGC2029
    EC.number 2.5.1.18, 5.2.1.2
    DNA
    TYPE functioning gene
    STRUCTURE 10.59 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ESRRB 14q24.3 estrogen-related receptor beta CYCSP1 14q24.3 cytochrome c, somatic pseudogene 1 LAMR1P3 14 laminin receptor 1 pseudogene 3 LOC388000 14 LOC388000 KIAA1036 14q24.3 LOC388000 KIAA0759 14q24.3 LOC388000 LOC145497 14q24.3 hypothetical protein LOC145497 RPL22P2 14 ribosomal protein L22 pseudogene 2 RPLP1P1 14q23 ribosomal protein, large, P1 pseudogene 1 C14orf4 14q24.3 chromosome 14 open reading frame 4 KIAA1737 14q24.3 KIAA1737 C14orf59 14 chromosome 14 open reading frame 59 C14orf171 14q24.3 chromosome 14 open reading frame 171 NGB 14q24 neuroglobin POMT2 14q24.3 protein-O-mannosyltransferase 2 GSTZ1 14q24.3 glutathione transferase zeta 1 (maleylacetoacetate isomerase) LOC283578 14q24.3 hypothetical protein LOC283578 LOC161394 14q24.3 hypothetical protein LOC161394 LOC122945 14q24.3 hypothetical protein FLJ32809 C14orf133 14q24.3-q31 chromosome 14 open reading frame 133 AHSA1 14q23.3-31 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) THSD3 14q24.3 thrombospondin, type I domain-containing 3 SPTLC2 14q24.3-q31 serine palmitoyltransferase, long chain base subunit 2 ALKBH 14q24 alkB, alkylation repair homolog (E. coli) RPL21P10 14 ribosomal protein L21 pseudogene 10 DC50 14q24.3 hypothetical protein DC50 SNW1 14q24.3 hypothetical protein DC50 FLJ25976 14q24.3 hypothetical protein FLJ25976 ADCK1 14q24.3 aarF domain containing kinase 1 FRDAP 14q24.3 Friedreich ataxia pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1395 24 216 - -
    - - 1269 19.2 174 - -
    - - 1485 17.7 161 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • GST superfamily
  • zeta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • glutathione-S-transferase
  • possessing glutathione peroxydase activity toward t-butyl and cumene hyperoxydes
  • possessing maleylacetoacetate isomerase activity
  • fundamental to the catabolism of aromatic AAs
  • last enzyme from the phenylalanine and tyrosine catabolic pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS