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FLASH GENE
Symbol GSTT2 contributors: KTN/npt - updated : 21/11/2008
HGNC name glutathione S-transferase theta 2
HGNC id 4642
Location 22q11.23      Physical location : 24.299.602 - 24.326.104
Synonym name GST class-theta-2
Synonym symbol(s) MGC182032
EC.number 2.5.1.18
DNA
TYPE functioning gene
SPECIAL FEATURE head to head, opposite orientation
text likely a pseudogene with a splice site abnormality and a premature translation stop signal (Coggan)
STRUCTURE 3.79 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
RAB36 22q11.2 RAB36, member RAS oncogene family BCR 22q11.23 breakpoint cluster region FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547 FLJ31568 22q11.23 hypothetical protein FLJ31568 LOC388882 22 hypothetical gene supported by BC036910 LOC388883 22 similar to Gag-Pro-Pol protein IGLL1 22q11.22 immunoglobulin lambda-like polypeptide 1 LOC391321 22 similar to Rhabdoid tumor deletion region protein 1 LOC51233 22q11.2 hypothetical protein LOC51233 LOC388884 22 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) ASLL 22q11.22 argininosuccinate lyase-like Rgr 22q11.23 Ral-GDS related protein Rgr ZNF70 22q11.22 zinc finger protein 70 (Cos17) VPREB3 22q11.2 pre-B lymphocyte gene 3 FLJ36561 22q11.23 hypothetical protein FLJ36561 MMP11 22q11.22 matrix metalloproteinase 11 (stromelysin 3) SMARCB1 22q11.23 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 FLJ43842 22q11.23 FLJ43842 protein SLC2A11 22q11.2 solute carrier family 2 (facilitated glucose transporter), member 11 MIF 22q11.22 macrophage migration inhibitory factor (glycosylation-inhibiting factor) LOC284890 22q11.23 similar to lymphocyte activation-associated protein; kelch (Drosophila)-like 5 DDT 22q11.23 D-dopachrome tautomerase GSTT2 22q11.23 glutathione S-transferase theta 2 HS322B1A 22q12 hypothetical protein HS322B1A LOC391322 22 similar to D-dopachrome tautomerase (Phenylpyruvate tautomerase II) GSTT1 22q11.23 glutathione S-transferase theta 1 LOC343854 22q11.23 similar to RIKEN cDNA 4930583C14 CABIN1 22q11.2-q12.3 similar to RIKEN cDNA 4930583C14 BK65A6.2 GGTLA1 22q11.2 gamma-glutamyltransferase-like activity 1 LOC339661 22q11.23 similar to Gamma-glutamyltransferase-like protein 4 DKFZP434P211 22q11.22 POM121-like protein LOC388885 22 LOC388885 KIAA0376 22q11.2-q12.3 LOC388885 ADORA2A 22q11.22 adenosine A2a receptor UPB1 22q11.2 ureidopropionase, beta MGC1842 22q11.2 hypothetical protein MGC1842 SNRPD3 22q11.21 small nuclear ribonucleoprotein D3 polypeptide 18kDa GGT1 22q11.23 gamma-glutamyltransferase 1 LOC388886 22 similar to hypothetical protein LOC192734 LOC343855 22q11.23 similar to POM121 membrane glycoprotein-like 1 LOC391323 22 similar to actin-related protein 2 LOC388887 22 LOC388887 BCRL6 22q11.22 breakpoint cluster region-like 6
regionally located . separated by 50kb from GSTT1, tighlty linked to DDT, in head to head disposition
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1136 27.4 244 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestivesalivary gland   predominantly
Endocrineadrenal gland   highly
Reproductivefemale systemuteruscervix moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a GST N-terminal domain
  • a GST C-terminal domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to chimpanzee GSTT2B (98.8 pc)
    homolog to rattus Gstt2 (78.3 pc)
    homolog to murine Gstt2 (77.4 pc)
    Homologene
    FAMILY
  • GST superfamily
  • theta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • playing an important role in human carcinogenesis
  • acting as a sulfatase
  • participating in detoxification and defense mechanisms against toxic carcinogens and other compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS