Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

GSTT2

contributors: KTN/npt - updated : 21/11/2008

HGNC name	glutathione S-transferase theta 2
HGNC id	4642

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q11.23      Physical location : 24.299.602 - 24.326.104
Synonym name	GST class-theta-2
Synonym symbol(s)	MGC182032
EC.number	2.5.1.18

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head, opposite orientation
text	likely a pseudogene with a splice site abnormality and a premature translation stop signal (Coggan)
STRUCTURE	3.79 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

regionally located

. separated by 50kb from GSTT1, tighlty linked to DDT, in head to head disposition

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GSTT2 5 - 1136 27.4 244 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive salivary gland       predominantly Endocrine adrenal gland       highly Reproductive female system uterus cervix   moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a GST N-terminal domain
	a GST C-terminal domain

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to chimpanzee GSTT2B (98.8 pc)
	homolog to rattus Gstt2 (78.3 pc)
	homolog to murine Gstt2 (77.4 pc)

Homologene

FAMILY	GST superfamily
	theta family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
	playing an important role in human carcinogenesis
	acting as a sulfatase
	participating in detoxification and defense mechanisms against toxic carcinogens and other compounds

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS