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FLASH GENE
Symbol GSTT1 contributors: mct/npt/pgu/shn - updated : 29-05-2011
HGNC name glutathione S-transferase theta 1
HGNC id 4641
Location 22q11.23      Physical location : 24.376.140 - 24.384.284
Synonym name
  • GST class-theta-1
  • glutathione transferase T1-1
  • glutathione S-transferase theta-1
  • EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    STRUCTURE 8.14 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S686 - D22S1685 - GSTT1 - D22S1174 - D22S925 - qter
    Physical map
    FBXW3 22q11 F-box and WD-40 domain protein 3 LOC343851 22q11.23 similar to hypothetical protein FLJ31547 FLJ31568 22q11.23 hypothetical protein FLJ31568 LOC388882 22 hypothetical gene supported by BC036910 LOC388883 22 similar to Gag-Pro-Pol protein IGLL1 22q11.22 immunoglobulin lambda-like polypeptide 1 LOC391321 22 similar to Rhabdoid tumor deletion region protein 1 LOC51233 22q11.2 hypothetical protein LOC51233 LOC388884 22 similar to Immunoglobulin lambda-like polypeptide 1 precursor (Immunoglobulin-related 14.1 protein) (Immunoglobulin omega polypeptide) (Lambda 5) (CD179b antigen) ASLL 22q11.22 argininosuccinate lyase-like Rgr 22q11.23 Ral-GDS related protein Rgr ZNF70 22q11.22 zinc finger protein 70 (Cos17) VPREB3 22q11.2 pre-B lymphocyte gene 3 FLJ36561 22q11.23 hypothetical protein FLJ36561 MMP11 22q11.22 matrix metalloproteinase 11 (stromelysin 3) SMARCB1 22q11.23 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 FLJ43842 22q11.23 FLJ43842 protein SLC2A11 22q11.2 solute carrier family 2 (facilitated glucose transporter), member 11 MIF 22q11.22 macrophage migration inhibitory factor (glycosylation-inhibiting factor) LOC284890 22q11.23 similar to lymphocyte activation-associated protein; kelch (Drosophila)-like 5 DDT 22q11.23 D-dopachrome tautomerase GSTT2 22q11.23 glutathione S-transferase theta 2 HS322B1A 22q12 hypothetical protein HS322B1A LOC391322 22 similar to D-dopachrome tautomerase (Phenylpyruvate tautomerase II) GSTT1 22q11.23 glutathione S-transferase theta 1 LOC343854 22q11.23 similar to RIKEN cDNA 4930583C14 CABIN1 22q11.2-q12.3 similar to RIKEN cDNA 4930583C14 BK65A6.2 GGTLA1 22q11.2 gamma-glutamyltransferase-like activity 1 LOC339661 22q11.23 similar to Gamma-glutamyltransferase-like protein 4 DKFZP434P211 22q11.22 POM121-like protein LOC388885 22 LOC388885 KIAA0376 22q11.2-q12.3 LOC388885 ADORA2A 22q11.22 adenosine A2a receptor UPB1 22q11.2 ureidopropionase, beta MGC1842 22q11.2 hypothetical protein MGC1842 SNRPD3 22q11.21 small nuclear ribonucleoprotein D3 polypeptide 18kDa GGT1 22q11.23 gamma-glutamyltransferase 1 LOC388886 22 similar to hypothetical protein LOC192734 LOC343855 22q11.23 similar to POM121 membrane glycoprotein-like 1 LOC391323 22 similar to actin-related protein 2 LOC388887 22 LOC388887 BCRL6 22q11.22 breakpoint cluster region-like 6 TOP1P2 22q11.2-q13.1 topoisomerase (DNA) I pseudogene 2 KIAA1941 22q11.23 KIAA1941 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1076 - 240 lung, kidney, brain, skeletal muscle, heart, small intestine and spleen - 8799324
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • polymorphic with conjugator (GSTT1+, non conjugator (GSTT1-) phenotypes
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gstt1, Mus musculus
    ortholog to Gstt1, Rattus norvegicus
    ortholog to GSTT1, Pan troglodytes
    Homologene
    FAMILY
  • GST superfamily
  • theta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole
  • catalyzing the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in bladder cancer and in adult acute myeloid leukemia
    Susceptibility
  • to age-related hearing impairment
  • to lung cancer concerning tobacco smoking
  • predisposition for developing leukopenia
  • to male infertility
  • to development of coronary artery disease in T2DM patients
  • Variant & Polymorphism other
  • significant risk for lung cancer concerning tobacco smoking was found in the association of null genotypes for GSTM1 and GSTT1
  • null genotypes (GSTT1 and GSTM1) are a potential biomarker of predisposition for developing leukopenia
  • increased risk of GSTM1 or GSTT1 null genotypes for developing male infertility, but the nondeletion GSTM1 and GSTT1 genotypes emerged as protective factors
  • GSTT1 null genotypes are associated with increased risk for senile cataract in Asian populations but not in Caucasian populations (
  • GSTT1 allele play a pivotal role in the development of coronary artery disease in T2DM patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS