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FLASH GENE
Symbol GSTT1 contributors: mct/npt/pgu/shn - updated : 29-05-2011
HGNC name glutathione S-transferase theta 1
HGNC id 4641
Location 22q11.23      Physical location : 24.376.140 - 24.384.284
Synonym name
  • GST class-theta-1
  • glutathione transferase T1-1
  • glutathione S-transferase theta-1
  • EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    STRUCTURE 8.14 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D22S686 - D22S1685 - GSTT1 - D22S1174 - D22S925 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1076 - 240 lung, kidney, brain, skeletal muscle, heart, small intestine and spleen - 8799324
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
    Endocrineparathyroid   highly
    Lymphoid/Immunetonsils   highly
    Nervousnervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • polymorphic with conjugator (GSTT1+, non conjugator (GSTT1-) phenotypes
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to Gstt1, Mus musculus
    ortholog to Gstt1, Rattus norvegicus
    ortholog to GSTT1, Pan troglodytes
    Homologene
    FAMILY
  • GST superfamily
  • theta family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in tautomerization of d-dopachrome with decarboxylation to give 5,6-dihydroxyindole
  • catalyzing the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in bladder cancer and in adult acute myeloid leukemia
    Susceptibility
  • to age-related hearing impairment
  • to lung cancer concerning tobacco smoking
  • predisposition for developing leukopenia
  • to male infertility
  • to development of coronary artery disease in T2DM patients
  • Variant & Polymorphism other
  • significant risk for lung cancer concerning tobacco smoking was found in the association of null genotypes for GSTM1 and GSTT1
  • null genotypes (GSTT1 and GSTM1) are a potential biomarker of predisposition for developing leukopenia
  • increased risk of GSTM1 or GSTT1 null genotypes for developing male infertility, but the nondeletion GSTM1 and GSTT1 genotypes emerged as protective factors
  • GSTT1 null genotypes are associated with increased risk for senile cataract in Asian populations but not in Caucasian populations (
  • GSTT1 allele play a pivotal role in the development of coronary artery disease in T2DM patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS