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FLASH GENE
Symbol GSTO1 contributors: mct - updated : 09-09-2011
HGNC name glutathione S-transferase omega 1
HGNC id 13312
Location 10q24.33      Physical location : 106.013.951 - 106.027.220
Synonym name
  • glutathione-S-transferase like
  • glutathione transferase omega
  • GSTO 1-1
  • Synonym symbol(s) GSTTLP28, P28, DKFZp686H13163
    EC.number 1.20.4.2 / 1.8.5.1
    DNA
    TYPE functioning gene
    STRUCTURE 12.54 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    ARL3 10q24.1 ADP-ribosylation factor-like 3 SFXN2 10q24.32 sideroflexin 2 C10orf26 10q24.33 chromosome 10 open reading frame 26 CYP17A1 10q24.3 cytochrome P450, family 17, subfamily A, polypeptide 1 LOC390000 10 similar to Tebp-pending-prov protein C10orf32 10q24.33 chromosome 10 open reading frame 32 CYT19 10q24.33 Cyt19 protein CNNM2 10q24.32 cyclin M2 NT5C2 10q24.32 5'-nucleotidase, cytosolic II LOC90470 10q24.33 similar to Ribulose-phosphate 3-epimerase (Ribulose-5-phosphate-3-epimerase) (HUSSY-17) INA 10q24.33 internexin neuronal intermediate filament protein, alpha RNF134 10q24.33 ring finger protein 134 TAF5 10q24 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa MGC14697 10q24.33 upregulated during skeletal muscle growth 5 LOC51063 10pter-q26.12 hypothetical protein LOC51063 LOC119395 10q24.33 hypothetical protein LOC119395 NEURL 10q25.1 neuralized-like (Drosophila) SH3MD1 10q24.33 SH3 multiple domains 1 FLJ22559 10q25.1 hypothetical protein FLJ22559 SLK 10q24.1-q25.2 SNF1 sucrose nonfermenting like kinase (yeast) COL17A1 10q24.3 collagen, type XVII, alpha 1 LOC119392 10q25.1 LOC119392 FLJ22944 10q25.1 hypothetical protein FLJ22944 GSTO1 10q24.33 glutathione S-transferase omega 1 GSTO2 10q25.1 glutathione S-transferase omega 2 KIAA1754 10q25.1 KIAA1754 protein LOC387710 10 LOC387710 FLJ35908 10q25.1 hypothetical protein FLJ35908 SORCS3 10q22-q26 hypothetical protein FLJ35908
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1017 27.4 241 widely expressed in many tissues 2000 10783391
  • capable of playing a major role in the glutathionylation cycle
  • 6 - 1070 - 213 - 2000 10783391
    5 - 918 - 208 - 2000 10783391
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain   lowly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal 19-20AA extension
  • thioredoxin-like domains
  • a glutathione binding site where glutathione can form a disulfide bond with a conserved active site cysteine residue positioned near the N-terminal end of helix 1
  • an active site cysteine residue that is essential for its primary catalytic activities
  • seven alpha helices abriting the C terminal
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine P28
    intraspecies homolog to GSTO2
    Homologene
    FAMILY
  • cytosolic glutathione transferase super family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • small stress response protein likely involved in cellular redox homeostasis
  • implicated in the post-translational processing and activation of the proinflammatory mediator interleukin-1B
  • inhibitor of cardiac muscle ryanodine receptor Ca2+ channels
  • nuclear translocation could be potentially involved in the stress response of human cells playing a role in the cancer progression of Barrett esophagus
  • two isozymes (GSTO1 and GSTO2) have significant DHA reductase (DHAR) activity
  • participates in the glutathionylation cycle and targets specific proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    appears to be associated with activation of survival pathways (Akt and ERK1/2) and inhibition of apoptotic pathways (JNK1), as well as protection against cisplatin-induced apoptosis
    Susceptibility
  • to variation of the age at onset of Alzheimer disease
  • to hepatocellular carcinoma, cholangiocarcinoma and breast cancer
  • Variant & Polymorphism insertion/deletion
  • polymorphic deletion of Glu-155 causes a deficiency of GSTO1 (by its low stability, resulting from its increased propensity to unfold), may contribute to the observed association of GSTO1 with the age at onset of Alzheimer disease
  • GSTO1*A140D polymorphism could play an important role as a risk factor for the development ofhepatocellular carcinoma, cholangiocarcinoma and breast cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS