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FLASH GENE
Symbol GSTM3 contributors: mct - updated : 17-07-2008
HGNC name glutathione S-transferase M3 (brain)
HGNC id 4635
Location 1p13.3      Physical location : 110.276.553 - 110.283.660
Synonym name
  • GST class-mu 3
  • S-(hydroxyalkyl)glutathione lyase M3
  • Synonym symbol(s) GST5, GSTM3-3, MGC3310, MGC3704, GSTB
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.00 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    KIAA0893 1p13.3 LOC388663 NDUFB3P1 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 1 AD-020 1p13.3 protein x 013 LOC391065 1 similar to poly(rC) binding protein 1; heterogenous nuclear ribonucleoprotein X; poly(rC)-binding protein 1; alpha-CP1; nucleic acid binding protein sub 2.3; heterogenous nuclear ribonucleoprotein E1 LOC127003 1p13.3 similar to CG5435-PA KIAA1324 1p13.2 maba1 SARS 1p13 seryl-tRNA synthetase CELSR2 1p21.16p13.3 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) DDA3 1p13.2 differential display and activated by p53 LOC343263 1p13.2 similar to Myosin-binding protein H (MyBP-H) (H-protein) SORT1 1p21.3-p13.1 Sortilin 1 PSMA5 1p13 proteasome (prosome, macropain) subunit, alpha type, 5 LOC388660 1 similar to mitsugumin29 LOC284612 1p13.2 hypothetical protein LOC284612 MGC46534 1p13.2 hypothetical protein MGC46534 FLJ39035 1p13.2 hypothetical protein FLJ39035 KIAA1163 1p13.2 amphoterin-induced gene GPR61 1p13.1 G protein-coupled receptor 61 GNAI3 1p13 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 GNAT2 1p13 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 AMPD2 1p21-p13 adenosine monophosphate deaminase 2 (isoform L) GSTM4 1p13.3 glutathione S-transferase M4 GSTM2 1p13.3 glutathione S-transferase M2 (muscle) GSTM1 1p13.3 glutathione S-transferase M1 GSTM5 1p13.3 glutathione S-transferase M5 GSTM3 1p13.3 glutathione S-transferase M3 (brain) EPS8L3 1p13.2-p11 EPS8-like 3 CSF1 1p21-p13.3 colony stimulating factor 1 (macrophage) AHCYL1 1p12 S-adenosylhomocysteine hydrolase-like 1 PRO0233 1p13.2 PRO0233 protein ALX3 1p23-p21 aristaless-like homeobox 3 LOC164153 1p13.2 similar to RIKEN cDNA 4930522D07 LOC388661 1 LOC388661 LOC388662 1 similar to Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4 KCNC4 1p21 potassium voltage-gated channel, Shaw-related subfamily, member 4 LOC388663 1 LOC388663
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3948 25 225 - Ikeda (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gstm3
    homolog to C.elegans T28A11.11
    Homologene
    FAMILY
  • GST superfamily
  • mu family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • establishment of blood/nerve barrier
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text germline maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypertension
  • to Alzheimer disease
  • Variant & Polymorphism other polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS