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FLASH GENE
Symbol GSTM3 contributors: mct - updated : 17-07-2008
HGNC name glutathione S-transferase M3 (brain)
HGNC id 4635
Location 1p13.3      Physical location : 110.276.553 - 110.283.660
Synonym name
  • GST class-mu 3
  • S-(hydroxyalkyl)glutathione lyase M3
  • Synonym symbol(s) GST5, GSTM3-3, MGC3310, MGC3704, GSTB
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 4.00 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3948 25 225 - Ikeda (2008)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gstm3
    homolog to C.elegans T28A11.11
    Homologene
    FAMILY
  • GST superfamily
  • mu family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • establishment of blood/nerve barrier
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    text germline maintenance
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to hypertension
  • to Alzheimer disease
  • Variant & Polymorphism other polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS