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FLASH GENE
Symbol GSTM2 contributors: npt/ - updated : 12-02-2004
HGNC name glutathione S-transferase M2 (muscle)
HGNC id 4634
Location 1p13.3      Physical location : 110.210.643 - 110.226.618
Synonym name
  • GST class-mu 2
  • GST, muscle
  • S-(hydroxyalkyl)glutathione lyase M2
  • glutathione S-transferase M1
  • Synonym symbol(s) GST4, GSTM, GSTM2-2, GTHMUS, MGC117303
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 7.22 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map 5' - GSTM4 - GSTM2 - GSTM1 - GSTM5 - 3'
    Authors Xu et al.(98)
    regionally located genes spacing approximately 20 kb apart
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1228 25.6 218 - -
    - - 1478 22.5 191 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gstm2
    homolog to C.elegans T28A11.11
    Homologene
    FAMILY
  • GST superfamily
  • mu family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • GSTM2-2 is a novel luminal regulator of the RyR channels in the heart (Wei 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    detoxification
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS