Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GSTM2 contributors: mct - updated : 22-12-2021
HGNC name glutathione S-transferase M2 (muscle)
HGNC id 4634
Location 1p13.3      Physical location : 110.210.643 - 110.226.618
Synonym name
  • GST class-mu 2
  • GST, muscle
  • S-(hydroxyalkyl)glutathione lyase M2
  • glutathione S-transferase M1
    • Synonym symbol(s) GST4, GSTM, GSTM2-2, GTHMUS, MGC117303
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 15.94 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map 5' - GSTM4 - GSTM2 - GSTM1 - GSTM5 - 3'
    Authors Xu et al.(98)
    regionally located genes spacing approximately 20 kb apart
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1166 25.6 218 - 1991 2034681
    9 - 1443 22.5 191 - 1991 2034681
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal half of GSTM2 (GSTM2C) is essential for RYR2 inhibition
    • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Gstm2
    homolog to C.elegans T28A11.11
    Homologene
    FAMILY
  • GST superfamily
  • mu family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    text
  • sarcoplasmic reticulum
    • basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • GSTM2-2 is a novel luminal regulator of the RyR channels in the heart (Wei 2008)
  • absence of GSTM1 activity can be compensated for by the overexpression of GSTM2
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    detoxification
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Ca(2+) release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RYR2) is essential for heart function and is inhibited by the C-terminal domain of glutathione transferase M2-2 (GSTM2-C)
  • GSTM2 inhibiting RYR2, in a manner that indicates a possible therapeutic potential for treatment of arrhythmia in the neonatal heart
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly associated with favorable prognosis in Colon adenocarcinoma (COAD)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS