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FLASH GENE
Symbol GSTA4 contributors: npt - updated : 13-01-2010
HGNC name glutathione S-transferase alpha 4
HGNC id 4629
Location 6p12.1      Physical location : 52.842.746 - 52.860.178
Synonym name
  • glutathione S-transferase A4
  • S-(hydroxyalkyl)glutathione lyase A4
  • glutathione S-aralkyltransferase A4
  • GST class-alpha member 4
    • Synonym symbol(s) RP1-214M20.1, DKFZp686D21185, GSTA4-4, GTA4
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 17.39 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ICK - GSTA@ - qter
    Authors Morel et al.(02)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1352 - 222 - Desmots (1998)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   lowly
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivefemale systemuterus   
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y45G12c.2
    Homologene
    FAMILY
  • GST superfamily
  • Alpha family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • glutathione S-transferase activity
  • play an important role in the protection against oxidative stress (Qian 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by carcinogens such as tobacco smoke (Qian 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS