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FLASH GENE
Symbol GSTA4 contributors: npt - updated : 13-01-2010
HGNC name glutathione S-transferase alpha 4
HGNC id 4629
Location 6p12.1      Physical location : 52.842.746 - 52.860.178
Synonym name
  • glutathione S-transferase A4
  • S-(hydroxyalkyl)glutathione lyase A4
  • glutathione S-aralkyltransferase A4
  • GST class-alpha member 4
  • Synonym symbol(s) RP1-214M20.1, DKFZp686D21185, GSTA4-4, GTA4
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 17.39 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - ICK - GSTA@ - qter
    Authors Morel et al.(02)
    Physical map
    IL17 2q31 interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8) IL17F 6p12 interleukin 17F SLC25A20P 6p12 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 pseudogene MCM3 6p12 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) C6orf33 6p12.1 chromosome 6 open reading frame 33 EFHC1 6p12.1 EF-hand domain (C-terminal) containing 1 TRAM2 6p21.3 translocation associated membrane protein 2 TMEM14A 6p12.3 transmembrane protein 14A LOC391927 6 similar to class-alpha glutathione S-transferase LOC391928 6 similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha) GSTA2 6p12.2 glutathione S-transferase A2 LOC391929 6 similar to glutathione transferase (EC 2.5.1.18) alpha-3 [similarity] - human GSTA1 6p12.2 glutathione S-transferase A1 GSTAP1 6p12.2 glutathione S-transferase A pseudogene 1 GSTA5 6p12.1 glutathione S-transferase A5 FLJ32293 6p12.3 hypothetical protein FLJ32293 GSTA3 6p12 glutathione S-transferase A3 GSTA4 6p12 glutathione S-transferase A4 RN7SK 6pter-p25 RNA, 7SK, nuclear ICK 6p12.3-p11.2 intestinal cell (MAK-like) kinase FBXO9 6p12.3-p11.2 F-box only protein 9 GCM1 6p21-p12 glial cells missing homolog 1 (Drosophila) LOC389398 6 LOC389398 ELOVL5 6p21.1-p12.1 ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast) LOC391930 6 similar to ribosomal protein L31 LOC391931 6 similar to replication protein A3, 14kDa; replication protein A3 (14kD) GCLC 6p12 glutamate-cysteine ligase, catalytic subunit LOC391932 6 similar to bA345L23.2 (novel protein with BTB/POZ (broad complex Tramtrack bric-a-brac/Pox virus and zinc finger) domain) LRRC1 6p12.1 leucine-rich repeat-containing 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1352 - 222 - Desmots (1998)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   lowly
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivefemale systemuterus   
    Respiratorylung   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text highly in placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y45G12c.2
    Homologene
    FAMILY
  • GST superfamily
  • Alpha family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • glutathione S-transferase activity
  • play an important role in the protection against oxidative stress (Qian 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by carcinogens such as tobacco smoke (Qian 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS