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FLASH GENE
Symbol GSTA1 contributors: mct/npt - updated : 15/102008
HGNC name glutathione S-transferase A1
HGNC id 4626
Location 6p12.2-p12.1      Physical location : 52.656.178 - 52.668.664
Synonym name
  • S-(hydroxyalkyl)glutathione lyase A1
  • GST, class alpha, 1
  • Synonym symbol(s) GST2, GSTA1-1, GTH1, MGC131939, GST-epsilon
    EC.number 2.5.1.18
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, head to head
    text closely flanked by other alpha class gene sequences
    STRUCTURE 12.27 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a proximal promoter essential for the binding of activating transcription factor complexes
    MAPPING cloned Y linked N status provisional
    Map cen - ICK - GSTA@ - qter
    Authors Morel (02)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1046 - 222 - Johnson (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     pharynx   highly
    Endocrineadrenal gland   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • GST superfamily
  • MU family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • conjugating reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
  • suppresses activation of JNK signalling by a pro-inflammatory cytokine and oxidative stress and have likely a protective role in JNK-associated apoptosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of A1 and A2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in high-grade prostatic intraepithelial neoplasia
    constitutional     --over  
    overexpressed in proliferative inflammatory atrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS