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FLASH GENE
Symbol GSPT2 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 2
HGNC id 4622
Location Xp11.22      Physical location : 51.486.480 - 51.489.324
Synonym name
  • peptide chain release factor 3b
  • eukaryotic peptide chain release factor subunit 3b
  • Synonym symbol(s) ERF3B, GST2, FLJ10441, eRF3b
    DNA
    TYPE functioning gene
    STRUCTURE 2.85 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - DXS1058 - DXS7045 - DXS1039 - DXS7048 - GSPT2 - DXS1199 - cen
    Authors Hansen (99)
    Physical map
    LOC139189 Xp11.23 similar to Diacylglycerol kinase, delta (Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase) KIAA1202 Xp11.23 similar to Diacylglycerol kinase, delta (Diglyceride kinase) (DGK-delta) (DAG kinase delta) (130 kDa diacylglycerol kinase) LOC347376 Xp11.23 similar to H3 histone, family 3B BMP15 Xp11.2 bone morphogenetic protein 15 LOC139193 Xp11.23 similar to nonhistone chromosomal protein HMG-1 - pig LOC392466 X similar to melanoma antigen LOC392467 X similar to melanoma antigen, family B, 4; melanoma-associated antigen B4 NUDT10 Xp11.23 nudix (nucleoside diphosphate linked moiety X)-type motif 10 LOC340602 Xp11.23 similar to CG32656-PA NUDT11 Xp11.23 nudix (nucleoside diphosphate linked moiety X)-type motif 11 LOC347549 Xp11.23 similar to nuclear protein p30 LOC392468 X similar to nuclear protein p30 LOC389857 X similar to nuclear protein p30 GSPT2 Xp11.23-p11.21 G1 to S phase transition 2 MAGED1 Xp11.23 melanoma antigen, family D, 1 LOC392469 X similar to importin 7; RAN binding protein 7 MAGED4 Xp11 similar to importin 7; RAN binding protein 7 GAGED3 Xp11.22-p11.21 G antigen, family D, 3 LOC392470 X similar to XAGE-5 protein LOC392471 X similar to XAGE-5 protein GAGED2 Xp11.21-Xp11.22 G antigen, family D, 2 psiSSX4 Xp11.2 SSX4 pseudogene psiSSX1 Xp11.2 SSX1 pseudogene SSX8 Xp11.23 synovial sarcoma, X breakpoint 8 SSX7 Xp11.23 synovial sarcoma, X breakpoint 7 psiSSX5 Xp11.2 SSX5 pseudogene SSX2 Xp11.23-p11.22 synovial sarcoma, X breakpoint 2 LOC387629 X synovial sarcoma, X breakpoint 3 LOC392472 X similar to synovial sarcoma, X breakpoint 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2861 68.7 628 - 1998 9712840
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Nervousbrain    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    cell cycle     cell cycle, checkpoint, G1S
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an elongation factor Tu domain
  • HOMOLOGY
    interspecies ortholog to murine Gspt2
    homolog to Drosophila Elf
    homolog to C.elegans H19N07.1
    intraspecies homolog to GSPT1
    Homologene
    FAMILY
  • GTP-binding elongation factor family
  • ERF3 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • translation elongation factor
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • GSPT2 originated through retrotransposition of processed GSPT1 transcript into the genome
  • CELLULAR PROCESS cell cycle, checkpoint
    protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule nucleotide,
  • GTP
  • protein
  • ETF1
  • GSPT2 overexpression alleviated the effect of GSPT1 silencing on readthrough and on ETF1 cellular levels
  • interaction between BIRC5 and GSPT1, GSPT2
  • biomarker for hepatocellular carcinoma, influencing cell cycle and phosphoralation status of EIF4EBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS