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Symbol GSPT1 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 1
HGNC id 4621
Location 16p13.13      Physical location : 11.961.986 - 12.010.519
Synonym name
  • peptide chain factor release 3
  • eukaryotic peptide chain release factor subunit 3a
  • Synonym symbol(s) ERF3, GST1, ETF3A, eRF3a, 551G9.2
    TYPE functioning gene
    STRUCTURE 48.53 kb     15 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • existence of potential promoter element in 5prime UTR of GSPT1 which is supposed to be responsible for GSPT2 transcription
  • MAPPING cloned Y linked N status confirmed
    Physical map
    ATF7IP2 16p13.2 activating transcription factor 7 interacting protein 2 EMP2 16p13.2 epithelial membrane protein 2 FLJ32871 16p13.2 hypothetical protein FLJ32871 NUBP1 16p13.1 nucleotide binding protein 1 (MinD homolog, E. coli) LOC283816 16p13.2 similar to ARHGAP21 protein MHC2TA 16p13 MHC class II transactivator DEXI 16p13.2 dexamethasone-induced transcript KIAA0350 16p13.13-p13.3 dexamethasone-induced transcript LOC390674 16 similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2) SOCS1 16p13.13 suppressor of cytokine signaling 1 TNP2 16p13.13 transition protein 2 (during histone to protamine replacement) PRM2 16p13.13 protamine 2 PRM1 16p13.13 protamine 1 MGC24665 16p13.2 hypothetical protein MGC24665 LOC388210 16 similar to CG15828-PA LOC388211 16 hypothetical gene supported by AK126539 LITAF 16p13.3-p12 lipopolysaccharide-induced TNF factor SNN 16p13 stannin LOC51061 16p13.13 hypothetical protein LOC51061 FLJ21777 16p13.13 hypothetical protein FLJ21777 HSPC055 16p13-p12 zinc-finger protein AY163807 LOC388212 16 LOC388212 DKFZP564M182 16p13.13 DKFZP564M182 protein GSPT1 16p13.13 G1 to S phase transition 1 COX6CP1 16p12 cytochrome c oxidase subunit VIc pseudogene 1 LOC348151 16p13.13 similar to nuclear pore complex interacting protein TNFRSF17 16p13.1 tumor necrosis factor receptor superfamily, member 17 FLJ12363 16p13.13 hypothetical protein FLJ12363 LOC92017 16p13.13 similar to RIKEN cDNA 4933437K13 LOC388213 16 LOC388213 FLJ11151 16p13.13 hypothetical protein FLJ11151
    regionally located mapping at the FRA16A locus
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 7190 - 499 - 1998 9712840
    15 - 7166 - 636 - 1998 9712840
    15 - 7169 - 637 - 1998 9712840
    - - - - - localized not only in the cytoplasm, but also in the nucleus 2014 24569073
  • may also function in the nucleus
    Type ubiquitous
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousspinal cord   highly
    Reproductivefemale systemuteruscervix highly
     female systembreastmammary gland highly
     male systemprostate  highly
     male systemtestis  highly
    cell lineage
    cell lines
    at STAGE
  • N-terminal unstructured domain (N-domain) and translation elongation factor EEF1A-like GTP-binding domain (C-domain)
  • a leptomycin-sensitive nuclear export signal (NES)
  • a region containing two overlapping PAM2 (PABPC1-interacting motif 2) motifs assumed to bind to the PABC domain of PABPC1
    interspecies homolog to yeast cell cycle,G1 to S phase transition 1
    intraspecies homolog to polypeptide chain elongation factor-1 alpha (EF1 alpha)
    FAMILY GTP-binding elongation factor family, ERF3 subfamily
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
  • is a nucleo-cutoplasmic shuttling protein
  • basic FUNCTION
  • involved in regulation of mammalian cell growth
  • mediating translation termination, and controling the formation of the termination complex by modulating ETF1 protein stability
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • is a GTPase associated with ETF1 in a complex that mediates translation termination in eukaryotes
  • eukaryotic translation termination is mediated by two interacting release factors, ETF1 and GSPT1, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release
  • ETF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase GSPT1 facilitates this peptide release via its interaction with ETF1
  • plays pivotal roles in translation termination and post-termination events including ribosome recycling and mRNA decay
  • could serve as a target in the regulation of gene expression
  • functional interplay between two release factors, ETF1 and GSPT1, involved in eukaryotic translation termination, and GTP hydrolysis by GSTP1 couples codon recognition with peptidyl-tRNA hydrolysis by ETF1
  • is a multifunctional protein that plays pivotal roles in translation termination as well as the initiation of mRNA decay, and also functions in the regulation of apoptosis
  • is a novel regulator of cell death
  • CELLULAR PROCESS nucleotide, transcription, elongation
    a component
    small molecule
  • interacting with and stimulating ETF1
  • expression level of GSPT1 controls the formation of the termination complex by modulating ETF1 protein stability
  • proteasomal degradation of GSTP1 controls translation termination complex formation by adjusting the GSPT1 level to that of ETF1
  • important role for ETF1 stimulatory effect on GSPT1 GTPase activity
  • interaction between BIRC5 and GSPT1, GSPT2
  • GSPT1 interact with BIRC5 through the N-terminal domain (NTD: residues 131-200)
  • JMJD4 interacts with the ETF1/GSPT1 translational termination complex in an activity-dependent manner
  • nucleocytoplasmic shuttling protein exported from the nucleus in a manner dependent on CRM1
  • cell & other
    Other controlled stop-codon directed release