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FLASH GENE
Symbol GSPT1 contributors: - updated : 04-07-2006
HGNC name G1 to S phase transition 1
HGNC id 4621
Location 16p13.13      Physical location : 11.961.986 - 12.010.519
Synonym name peptide chain factor release 3
Synonym symbol(s) ERF3
DNA
TYPE functioning gene
STRUCTURE 43.00 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
ATF7IP2 16p13.2 activating transcription factor 7 interacting protein 2 EMP2 16p13.2 epithelial membrane protein 2 FLJ32871 16p13.2 hypothetical protein FLJ32871 NUBP1 16p13.1 nucleotide binding protein 1 (MinD homolog, E. coli) LOC283816 16p13.2 similar to ARHGAP21 protein MHC2TA 16p13 MHC class II transactivator DEXI 16p13.2 dexamethasone-induced transcript KIAA0350 16p13.13-p13.3 dexamethasone-induced transcript LOC390674 16 similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1 / hnRNP C2) SOCS1 16p13.13 suppressor of cytokine signaling 1 TNP2 16p13.13 transition protein 2 (during histone to protamine replacement) PRM2 16p13.13 protamine 2 PRM1 16p13.13 protamine 1 MGC24665 16p13.2 hypothetical protein MGC24665 LOC388210 16 similar to CG15828-PA LOC388211 16 hypothetical gene supported by AK126539 LITAF 16p13.3-p12 lipopolysaccharide-induced TNF factor SNN 16p13 stannin LOC51061 16p13.13 hypothetical protein LOC51061 FLJ21777 16p13.13 hypothetical protein FLJ21777 HSPC055 16p13-p12 zinc-finger protein AY163807 LOC388212 16 LOC388212 DKFZP564M182 16p13.13 DKFZP564M182 protein GSPT1 16p13.13 G1 to S phase transition 1 COX6CP1 16p12 cytochrome c oxidase subunit VIc pseudogene 1 LOC348151 16p13.13 similar to nuclear pore complex interacting protein TNFRSF17 16p13.1 tumor necrosis factor receptor superfamily, member 17 FLJ12363 16p13.13 hypothetical protein FLJ12363 LOC92017 16p13.13 similar to RIKEN cDNA 4933437K13 LOC388213 16 LOC388213 FLJ11151 16p13.13 hypothetical protein FLJ11151
regionally located mapping at the FRA16A locus
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousspinal cord   highly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland highly
 male systemprostate  highly
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast cell cycle,G1 to S phase transition 1
intraspecies homolog to polypeptide chain elongation factor-1 alpha (EF1 alpha)
Homologene
FAMILY GTP-binding elongation factor family, ERF3 subfamily
CATEGORY regulatory , signaling cytokine
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
basic FUNCTION
  • involved in regulation of mammalian cell growth
  • mediating translation termination, and controling the formation of the termination complex by modulating ETF1 protein stability
  • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with and stimulating ETF1
    cell & other
    REGULATION
    Other controlled stop-codon directed release
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS