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FLASH GENE
Symbol GSKIP contributors: mct/npt - updated : 10-07-2008
HGNC name chromosome 14 open reading frame 129
HGNC id 20343
Location 14q32.2      Physical location : -
Synonym name GSK3beta interaction protein
Synonym symbol(s) C14orf129, HSPC210, MGC4945
DNA
TYPE functioning gene
STRUCTURE 7.00 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 2110 15.6 139 - Ewing (2007)
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineparathyroid   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 25-amino acid region in the C-terminus highly similar to the GSK3B interaction domain (GID) of Axin
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • naturally occurring protein homologous with the GSK3B interaction domain of Axin that is able to negatively regulate GSK3B of the Wnt signaling pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS