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FLASH GENE
Symbol GSDMD contributors: SGE - updated : 04-06-2007
HGNC name gasdermin D
HGNC id 25697
Location 8q24.3      Physical location : 144.635.556 - 144.645.229
Synonym name
  • DFNA5-like gene
  • gasdermin domain containing 1
  • Synonym symbol(s) DF5L, FLJ12150, DFNA5L, FKSG10, GSDMDC1
    DNA
    TYPE functioning gene
    STRUCTURE 4.00 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1823 52.6 484 - Katoh, 2004
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Lymphoid/Immunespleen   highly
     thymus   highly
     tonsils   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    cell lineage expressed in differentiating cells
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Gsdmdc1
    Homologene
    FAMILY
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in the regulation of cell growth and differentiation in the skin and/or hair follicle epithelium, as well as the epithelium of the gastrointestinal tract
  • may be a tumor suppressor (Saeki, 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic cancer, prostate cancer, melanoma, salivary gland tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS