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FLASH GENE

Symbol

GSDMA

contributors: mct/npt - updated : 05-01-2010

HGNC name	gasdermin A
HGNC id	13311

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q21.1      Physical location : 38.119.225 - 38.134.019
Synonym name	gasdermin 1
Synonym symbol(s)	GSDM, FLJ39120, FKSG9, MGC129596, GSDM1

DNA

TYPE	functioning gene
STRUCTURE	14.79 kb     12 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178171 12 - 2164 NP_835465 - 445 - Saeki (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Endocrine thyroid         Respiratory respiratory tract larynx       Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to murine Gsdm1

intraspecies

homolog to GSDML

Homologene

FAMILY

gasdermin family

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
text	expressed in the mucus-secreting pit cells of the gastric epithelium (Saeki 2007)

basic FUNCTION	may have an activity adverse to malignant transformation of cells
	may be playing a role in differentiation of the epidermis and its appendages
	involved in the regulation of cell growth and differentiation in the skin and/or hair follicle epithelium, as well as the epithelium of the gastrointestinal tract
	having a highly apoptotic activity (Saeki 2007)
	regulates apoptosis of the gastric epithelium (Saeki 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis

a component

INTERACTION

DNA

RNA

small molecule

protein

target of LMO1 in TGF-beta-dependent apoptotic signalling (Saeki 2007)

cell & other

REGULATION

Other

regulated by a transcription factor LIM domain only 1 (LMO1) through a sequence to which Runt-related transcription factor 3 (RUNX3) binds, in the promoter region (Saeki 2007)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         suppressed in gastric cancer cells

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS