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FLASH GENE
Symbol GSDMA contributors: mct/npt - updated : 05-01-2010
HGNC name gasdermin A
HGNC id 13311
Location 17q21.1      Physical location : 38.119.225 - 38.134.019
Synonym name gasdermin 1
Synonym symbol(s) GSDM, FLJ39120, FKSG9, MGC129596, GSDM1
DNA
TYPE functioning gene
STRUCTURE 14.79 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2164 - 445 - Saeki (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrinethyroid    
Respiratoryrespiratory tractlarynx   
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gsdm1
intraspecies homolog to GSDML
Homologene
FAMILY
  • gasdermin family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text expressed in the mucus-secreting pit cells of the gastric epithelium (Saeki 2007)
    basic FUNCTION
  • may have an activity adverse to malignant transformation of cells
  • may be playing a role in differentiation of the epidermis and its appendages
  • involved in the regulation of cell growth and differentiation in the skin and/or hair follicle epithelium, as well as the epithelium of the gastrointestinal tract
  • having a highly apoptotic activity (Saeki 2007)
  • regulates apoptosis of the gastric epithelium (Saeki 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of LMO1 in TGF-beta-dependent apoptotic signalling (Saeki 2007)
  • cell & other
    REGULATION
    Other regulated by a transcription factor LIM domain only 1 (LMO1) through a sequence to which Runt-related transcription factor 3 (RUNX3) binds, in the promoter region (Saeki 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    suppressed in gastric cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS