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FLASH GENE
Symbol GRWD1 contributors: - updated : 25-06-2005
HGNC name glutamate-rich WD repeat containing 1
HGNC id 21270
Location 19q13.33      Physical location : 48.949.029 - 48.957.163
Synonym name
  • WD repeat domain 28
  • glutamate rich WD repeat protein GRWD
    • Synonym symbol(s) WDR28, GRWD
    DNA
    TYPE functioning gene
    STRUCTURE 7.00 kb     7 Exon(s)
    regulatory sequence Promoter
    text structure 2 potential transcriptional regulatory regions in the promoter
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemovary  highly
     female systemuteruscervix highly
    Skin/Tegumentskin   highly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a glutamic/aspartic acid-rich domain of 14 consecutive AA from position 123 to 136
  • four WD repeats
    • HOMOLOGY
    interspecies homolog to yeast Rrb1
    Homologene
    FAMILY PSCD family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • ribosome assembly activity
  • playing a role in ribosome biogenesis and regulated during myeloid differentiation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by vitamin D3
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS