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FLASH GENE
Symbol GRSF1 contributors: mct - updated : 10-07-2015
HGNC name G-rich RNA sequence binding factor 1
HGNC id 4610
Location 4q13.3      Physical location : 71.681.498 - 71.705.627
Synonym name
  • Guanine-rich sequence binding factor 1
  • DNA
    TYPE functioning gene
    STRUCTURE 24.51 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 6646 - 480 - -
    10 - 6482 - 318 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three RNA recognition motif
  • two polyadenylation signal
  • RNA binding domain designated RNA recognition motif (RRM)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    intracellular,cytoplasm,cytosolic
    text
  • located in the nucleus as well as in the cytoplasm (PMID;
  • targeted to mitochondria where it forms granules that colocalize with foci of newly synthesized mtRNA next to mitochondrial nucleoids (PMID;
  • previously reported to localize in the cytosol, but an isoform of GRSF1 accumulates in discrete foci in the mitochondrial matrix (PMID;
  • basic FUNCTION
  • playing a role in the binding of RNAS containing the 14 bases G-rich element
  • mRNA-binding protein involved in translation activation
  • functions by selectively recruiting cellular and viral mRNAs containing 5prime UTR GRSF1 binding sites to polyribosomes, which is mediated through interactions with cellular proteins
  • implicated in the influenza viral life cycle, embryonic brain development and the regulation of apoptosis
  • functional component of several cellular signalling pathways as well as of the regulation of the cellular redox homeostasis
  • is a key regulator of posttranscriptional mitochondrial gene expression
  • regulates RNA processing in mitochondrial RNA granules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding to G-rich RNA
    small molecule
    protein
  • GRSF1 up-regulates translation of GPX4 mRNA and implicate the two proteins in embryonic brain development
  • preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the MT-ND6 mRNA, and the long noncoding RNAs for MT-CYB and MT-ND5
  • interact with RNase P and required for processing of both classical and tRNA-less RNA precursors
  • GRSF1 controls translation of the SNARE protein USE1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS