Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GRPR contributors: mct - updated : 31-08-2013
HGNC name gastrin-releasing peptide receptor
HGNC id 4609
Location Xp22.2      Physical location : 16.141.423 - 16.171.640
Synonym name
  • GRP-preferring bombesin receptor
  • Synonym symbol(s) GRPR1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE
    text escaping X-inactivation
    STRUCTURE 30.22 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif
    text structure CRE motif required to promoter activity in duodenal cancer cells
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2681 - 384 - 2007 17349623
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal glandcortex  lowly
    Nervousbrainlimbic system  highly Mus musculus
    Reproductivefemale systembreastmammary gland  
     male systemtestis   
    Respiratorylung    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Grpr
    Homologene
    FAMILY g protein coupled receptor family 1
    CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • acting through the phosphatidylinositol Ca2+ second messenger system
  • regulates ERK through multiple pathways in a single cell type depending upon receptor expression and agonist concentration
  • mediates gastrointestinal motility and hormone and neurotransmitter release in the gut, intestine, colon, and other organs
  • GRP and GRPR have important oncogenic properties beyond their established mitogenic functions
  • is an alternative chemotactic receptor that may play a role in the pathogenesis of inflammatory disorders
  • GRP and GRPR are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CREB1 is a critical regulator of human GRPR expression in gastrointestinal cancer and might be activated through different upstream intracellular pathways
  • triggers neutrophil recruitment both indirectly, through macrophages, as well as directly, binding to GRPR in these cells
  • interaction between GRPR and CXCR2, implicating some level of hierarchy or cooperation between the two receptors
  • PTK2 is a critical downstream regulator of GRPR, which mediates tumorigenesis and metastasis in neuroblastoma
  • GRP is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs
  • cell & other
    REGULATION
    induced by nicotine
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian tumor vessels
    tumoral     --over  
    in cancer cells
    tumoral     --over  
    in neoplastic cells of most prostate cancers and some renal cell cancers and in the tumoral vessels of urinary tract cancers
    Susceptibility tobacco-induced lung cancer by women
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    ovary tumor vessels might be targeted with bombesin analogs for diagnosis or for therapy
    cancerbrain 
    may be an ideal therapeutic target for the treatment of aggressive neuroblastomas
    ANIMAL & CELL MODELS
  • mice lacking Grpr presented with deficient light-induced phase shift in activity as well altered emotional learning and amygdala function