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FLASH GENE
Symbol GRP contributors: mct - updated : 31-08-2013
HGNC name gastrin-releasing peptide
HGNC id 4605
Location 18q21.31      Physical location : 56.887.399 - 56.898.000
Synonym name
  • DNA segment, single copy, probe 302R
  • mammalian equivalent of the amphibian tetradecapeptide bombesin
  • Synonym symbol(s) D18S95, BN, GRP-10, preproGRP, proGRP
    DNA
    TYPE functioning gene
    STRUCTURE 10.60 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 863 - 148 - 2006 16682780
    3 - 842 - 141 - 2006 16682780
    3 - 844 - 138 - 2006 16682780
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamusnucleus accumbens  Homo sapiens
     gangliasensory gangliadorsal root   Homo sapiens
    Reproductivemale systemprostate   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    isoforms Precursor preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C
    HOMOLOGY
    Homologene
    FAMILY bombesin/neuromedin B/ranatensin family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulating gastrin release as well as other gastrointestinal hormones
  • GRP and GRPR have important oncogenic properties beyond their established mitogenic functions
  • GRP-containing neurons in the paraventricular nucleus may be part of the hypothalamic signaling pathway controlling food intake and energy balance
  • plays an important role in regulating tumor growth and migration
  • communicates photic phase setting signals in the SCN (suprachiasmatic nucleus) by increasing neurophysiological activity of SCN neurons
  • neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both central and peripheral nervous systems
  • triggers neutrophil recruitment both indirectly, through macrophages, as well as directly, binding to GRPR in these cells
  • has a selective effect over neutrophils in vivo, inducing their migration through activation of GRPR
  • stimulate the proliferation and invasiveness of androgen-independent prostate carcinoma
  • could function locally in the dorsal spinal cord in addition to its roles in DRG neurons
  • GRP) is a regulatory peptide that acts through its receptor (GRPR) to regulate physiological functions in various organs
  • neuropeptide that acts through G protein coupled receptors and is involved in signal transmission in both the central and peripheral nervous systems
  • GRP and GRPR are relevant to the inflammatory response, being a potential therapeutic target several diseases are related to inflammation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PI3K is essential for GRP-induced neutrophil migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer with aggressive phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS