| basic FUNCTION
| having growth modulatory activity |
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having possible cytokine-like activity |
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may play a role in inflammation, wound repair, |
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and tissue remodeling (being a crucial mediator of wound response and tissue repair) |
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involved in the stimulation of chondrocyte proliferation (stimulation mediated by COMP) |
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may act as a wound-healing factor, although the granulins and the full-length PGRN may have opposite functions in wound repair and inflammation |
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germ cell-specific glycoprotein that was expressed meiotically and post-meiotically, having growth-modulating properties  |
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importance of progranulin as neuroprotective growth factor |
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important role in tooth formation during postnatal development |
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function for progranulin in modulating the kinetics of programmed cell death that may be relevant for neuron loss in neurodegenerative diseases |
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neurotrophic factor that enhances neuronal survival and axonal growth |
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GRN growth factor, JUNB, and MYOD1 transcription factor form a regulatory loop and act in concert in the course of myogenesis |
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hepatic oncofetal protein regulating ES cell-related signaling molecules |
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key adipokine that mediates HFD (high fat diet)-induced insulin resistance and obesity through production of IL6 in adipose tissue |
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microglial PGRN appears to function as an endogenous modulator of innate immune responses |
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widely expressed secreted protein that is linked to inflammation |
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critical role of GRN in lysosomes |
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is a secretory lysosomal protein that regulates lysosomal function and biogenesis by controlling the acidification of lysosomes |
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role of GRN insufficiency in the pathogenesis of neurodegenerative diseases |
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is likely essential for proper lysosomal function |
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