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FLASH GENE
Symbol GRM8 contributors: mct - updated : 19-10-2015
HGNC name glutamate receptor, metabotropic 8
HGNC id 4600
Location 7q31.33      Physical location : 126.078.651 - 126.892.428
Synonym symbol(s) FLJ41058, GLUR8, GPRC1H, MGC126724, MGLUR8, mGlu8
DNA
TYPE functioning gene
STRUCTURE 813.78 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
text structure likely somme more exons
MAPPING cloned Y linked N status provisional
Map cen - D7S686 - [D7S1873 - D7S1801 - D7S1822 - D7S1874 ] - D7S680 - D7S514 - D7S635 - qter
Authors Scherer (96,97)
Text [location of GRM8 with internal microsatellite markers]
Physical map
LOC136157 7q31.33 similar to RIKEN cDNA 1500011L16 LOC346643 7q31.33 similar to 40S ribosomal protein S2 GPR37 7q31 G protein-coupled receptor 37 (endothelin receptor type B-like) LOC154872 7q31.33 hypothetical LOC154872 POT1 7q31.33 protection of telomeres 1 LOC392094 7 similar to Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) (PRO1608) GRM8 7q31.3-q32.1 glutamate receptor, metabotropic 8 LOC346646 7q32.2 similar to Protein C20orf45 (CGI-107) LOC168850 7q32.2 hypothetical protein LOC168850 GCC1 7q22.3 golgi coiled-coil 1 ARF5 7q31.3 ADP-ribosylation factor 5 FSCN3 7q31.3 fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus) PAX4 7q32 paired box gene 4 SND1 7q31.3 paired box gene 4 NSG-X 7q31 brain and nasopharyngeal carcinoma susceptibility protein LRRC4 7q31 leucine rich repeat containing 4 LEP 7q31.3 leptin (obesity homolog, mouse) MGC27345 7q32.2 hypothetical protein MGC27345 FLJ10377 7q32.2 hypothetical protein FLJ10377 LOC389551 7 hypothetical gene supported by BC063892 IMPDH1 7q31.3-q32 IMP (inosine monophosphate) dehydrogenase 1 HIG2 7q32.2 hypoxia-inducible protein 2 METTL2 17q24.1 methyltransferase like 2 LOC389552 7 similar to Serine/threonine-protein kinase tousled-like 2 (Tousled-like kinase 2) (PKU-alpha) LOC389553 7 hypothetical gene supported by AL137733 LOC389554 7 hypothetical gene supported by BC062355
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3572 - 909 - 1999 10216218
  • hmGluR8a
  • 11 splicing 3873 - 908 fetal and adult brain 2011 21288202
  • hmGluR8b
  • 55bp insertion leading to a change in the C terminal 16AA
  • PIAS1 and PIAS3 interacted strongly with mGluR8b, and were co-localized with the E2-conjugating UBE2I, SUMO1 and mGluR8b in cell bodies present in the ganglion cell layer of the mammalian retina
  • - splicing 3229 - 501 predominantly in brain Mallerbe
    74bp insertion before the TM region leading to a secreted form
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Hearing/Equilibriumearinner    Homo sapiens
    Nervousbrain    
    Reproductivemale systemtestis   
    Respiratorylung    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousglia
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane segments (7TM) receptor
  • an extended intracellular C-terminal domain (CTD) presumed to allow for modulation of downstream signaling
  • HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • metabotropic glutamate receptor, groupe III, linked to the inhibition of cAMP cascade
  • presynaptic metabotropic glutamate receptors (mGluRs) playing a central role in regulating presynaptic activity through G-protein effects on ion channels and signal transducing enzymes
  • play a pivotal role in the development of the central nervous system
  • RELN and GRM8 genes are likely involved in the pathogenesis of autistic disorder
  • CDH13, GRM8, ANK2, SLC16A6, ARSG, RIMBP2 and DCLK1 having role in hearing function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding to PIAS1 (required a region N-terminal to a consensus sumoylation motif)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS