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FLASH GENE
Symbol GRM7 contributors: mct/npt - updated : 30-05-2009
HGNC name glutamate receptor, metabotropic 7
HGNC id 4599
Location 3p26.1      Physical location : 6.902.801 - 7.783.218
Synonym symbol(s) GLUR7, MGLUR7, MGR7, GPRC1G, FLJ40498
DNA
TYPE functioning gene
STRUCTURE 880.29 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site
text structure calmodulin and G beta gamma binding sites
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 4300 - 915 brain, fetal brain, retina Schulz (2002)
unique 16 AAs terminus encoded by exon 10
13 - - - 923 non neuronal tissues (trachea, testis uterus placenta, salivary gland) Schulz (2002)
  • exons 9-9b-9c-9d-9e
  • unique 25 AAs terminus encoded by exon 9b-9c
  • 12 - - - 904 non neuronal tissues (trachea, testis uterus placenta, salivary gland) Schulz (2002)
  • exons 9c-9d-9e
  • unique 12 AAs terminus encoded by exon 9c
  • 11 - - - 902 brain, retina Schulz (2002)
  • exons 9d-9e
  • unique 7 AAs terminus encoded by exon 9d
  • 11 - 4113 - 922 fetal brain, brain, retina Schulz (2002)
  • exons 9-9a-10
  • unique 23 AAs terminus encoded by exon 9a
  • EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinner   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Hearing / Equilibriumcochlea cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • calmodulin binding motif at the C terminus
  • large extracellular domain preceding the 7 membrane spanning domains
  • an alpha tubulin-binding site located within AAs 873-892 of the CT domain, a region known to be important for regulation of GRM7 trafficking (Saugstad 2002)
  • HOMOLOGY
    interspecies homolog to C.elegans Mgl1
    homolog to rattus mglur7
    Homologene
    FAMILY
  • G-protein coupled receptor 3 family
  • CATEGORY signaling neurotransmitter , receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a role in the inhibition of the cyclic AMP cascade
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with PICK1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with PICK1
  • interaction with TUBA1A (GRM7/alpha tubulin interaction may provide a mechanism to control access of the CT domain to regulatory molecules, or alternatively, that this interaction may lead to morphological changes in the presynaptic membrane in response to receptor activation) (Saugstad 2002)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to age-related hearing impairment (ARHI)
  • attention-deficit/hyperactivity disorder
  • Variant & Polymorphism SNP
  • contribute to an individual risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity (Friedman 2009)
  • SNP associated to attention-deficit/hyperactivity disorder (Mick 2008)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS