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FLASH GENE
Symbol GRM6 contributors: mct - updated : 09-03-2016
HGNC name glutamate receptor, metabotropic 6
HGNC id 4598
Corresponding disease
CSNB1B blindness night congenital, stationary 1B, Schubert-Bornschein type
Location 5q35.3      Physical location : 178.405.331 - 178.422.124
Synonym symbol(s) MGLUR6, MGR6, GPRC1F, mGlu6
DNA
TYPE functioning gene
STRUCTURE 16.80 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
text structure cpg in exon 1
MAPPING cloned Y linked   status provisional
Physical map
LOC285647 5q35.3 similar to FLJ00052 protein PROP1 5q11.2 prophet of Pit1, paired-like homeodomain transcription factor LOC389350 5 similar to KIAA0752 protein LOC285658 5q35.3 similar to 60S ribosomal protein L19 N4BP3 5q35.3 similar to 60S ribosomal protein L19 FLJ22318 5q35.3 hypothetical protein FLJ22318 NOLA2 5q35 nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs) GMCL 5q35.3 germ cell-less homolog (Drosophila) HNRPAB 5q35.3 heterogeneous nuclear ribonucleoprotein A/B MGC15875 5q35.3 hypothetical protein MGC15875 COL23A1 5q35.3 collagen, type XXIII, alpha 1 MRPL50P3 5p12 collagen, type XXIII, alpha 1 CLK4 5q35 CDC-like kinase 4 ZNF354A 5q35.3 zinc finger protein 354A LOC391856 5 similar to acetoacetyl-CoA synthetase; acetoacetate-CoA ligase; homolog of C. elegans supressor of ras 5 (sur-5) LOC391857 5 similar to hypothetical protein MGC2574 ZNF354B 5q35-3 zinc finger protein 354B LOC340042 5q35.3 similar to hypothetical protein MGC48972 PIGFP1 5q35 phosphatidylinositol glycan, class F, pseudogene 1 FLJ21628 5q35.3 hypothetical protein FLJ21628 ZNF454 5q35.3 zinc finger protein 454 GRM6 5q35 glutamate receptor, metabotropic 6 LOC391858 5 similar to F-box and WD-40 domain protein 2 LOC345462 5q35.3 similar to hypothetical protein 9630041N07 ZNF354C 5q35.3 zinc finger protein 354C LOC345463 5q35.3 similar to UNR protein ADAMTS2 5q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 LOC391859 5 similar to Tb-291 membrane associated protein LOC389351 5 similar to 6-pyruvoyl-tetrahydropterin synthase RUFY1 5q35.3 RUN and FYVE domain containing 1 HNRPH1 5q353 heterogeneous nuclear ribonucleoprotein H1 (H) LOC202404 5q35.3 hypothetical LOC202404 LOC285679 5q35.3 hypothetical protein LOC285679 LOC389352 5 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) CANX 5q35 calnexin MAML1 5q35 mastermind-like 1 (Drosophila) FLJ12121 5q35.3 hypothetical protein FLJ12121 LTC4S 5q35 leukotriene C4 synthase MGAT4B 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 6143 - 877 - Hashimoto
- - - - 425 - Valerio
lack 97 nucleotides from exon 6
- - - - 405 - Valerio
lack 5 nucleotides of exon 5
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualbipolar cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • a signal peptide of 24 AA
  • a ligand-binding domain, poorly characterized cysteine-rich domains, in addition to the intracellular domains, having a pivotal role in correct trafficking of metabotropic glutamate receptors to the cell surface
  • HOMOLOGY
    interspecies homolog to C.elegans Y4C6A.2
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text photoreception
    basic FUNCTION
  • metabotropic glutamate receptor, groupe III, linked to the inhibition of cAMP cascade
  • neurotransmitter receptor present only in the synapses of the ON bipolar cell dendrites, and mediating synaptic transmission from rod and cone photoreceptors to this type of second-order neuron
  • in retinal ON bipolar cells, Go couples the metabotropic receptor GRM6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • GNB3 participates in the G-protein heterotrimer that couples GRM6 to TRPM1
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSNB1B
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS