basic FUNCTION
| glutamate receptor group I, activating phosphatidylinositol turnover and triggering intracellular calcium release |
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important neuronal mediator of postsynaptic signaling that influence synaptic strength, plasticity, and other factors |
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plays a pivotal role as a modulator of synaptic plasticity, ion channel activity and excitotoxicity |
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group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C |
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plays a role in pain and addiction |
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critical to the function of neural circuits that are required for inhibitory learning mechanisms, suggesting that targeting metabotropic receptors may be useful in treating psychiatric disorders in which aversive memories are inappropriately retained |
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important for synaptic transmission and synaptic plasticity |
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involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia |
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with GRM1, plays a role in the early stages of corticogenesis with, however, a different contribution to human cortical developmental events |
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is a GPCR that plays a crucial role in circuit formation in the brain and also in various forms of synaptic plasticity including learning and memory |
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likely does not get degraded and recycles back to the cell membrane after constitutive endocytosis |
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constitutively endocytosed GRM5 goes to the recycling compartment subsequent to internalization while very little or no receptors enter the lysosomal compartment |
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stress induces a cognitive deficit that is likely mediated by GRM5/HOMER1 signaling in the hippocampus |
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GRM1, GRM5 play critical functions in forms of activity-dependent synaptic plasticity and synapse remodeling in physiological and pathological states |
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GRM1, GRM5 are key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the thalamic reticular nucleus (TRN) |