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FLASH GENE
Symbol GRIN3B contributors: mct - updated : 07-10-2011
HGNC name glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
HGNC id 16768
Location 19p13.3      Physical location : 1.000.436 - 1.009.723
Synonym symbol(s) NR3B
DNA
TYPE functioning gene
STRUCTURE 9.29 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
regionally located . located between WDR18 and C19orf6 (membralin)
RNA
TRANSCRIPTS type messenger
text previously uncharacterized regulation of NMDA receptor function by alternative splicing of the GRIN3B subunit (PMID: 21320125)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3270 - 1043 - 2002 12008020
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbrainmedulla oblongata  
 brainmidbrain   
 brainlimbic systemhippocampusdentate gyrus  Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
 brainbasal nucleiputamen   Homo sapiens
 spinal cord    
Respiratorylung   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 14 aa signal peptide
  • a potential site for calcium/calmodulin-dependent protein kinase type 2
  • an extracellular ligand binding domain
  • four transmembrane segments
  • conjugated GlycoP
    mono polymer heteromer , trimer , complex
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Grin3b
    homolog to murine Nr3b
    intraspecies homolog to GRIN3A
    Homologene
    FAMILY
  • glutamate-regulated superfamily of ion channels
  • N-methyl-D-asparate family
  • CATEGORY regulatory , receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text postsynaptic membrane
    basic FUNCTION
  • excitatory glycine receptor relatively Ca2+ impermeable and resistant to Mg2+
  • involved in synapse formation, in regulation of synaptic plasticity and neuronal death
  • suppressing glutamate induced currents, a NMDA receptor dominant negative
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • development of synaptic elements by modulating NMDA receptor activity
  • ion transport
  • PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • forming heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B)
  • found in a complex containing GRIN1 and GRIN2A
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
  • GRIN1 to form excitatory glycine receptor
  • cross-talk between GRIN3B and NR4A1 receptors is a mechanism modulating the transcriptional activities of these orphan nuclear receptors
  • co-expression of both GRIN3A and GRIN3B subunits is essential for the dominant negative properties on Ca(2+) mobilization through acquired functional NMDAR channels into mitochondria
  • cell & other
    REGULATION
    Other unaffected by glutamate and NMDA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    is a long lasting result of opioid abuse
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • considerable decrease in the up-regulated state of the GRIN3B subunit by methadone may represent another benefit of methadone therapy for opioid addicts and may serve as a suitable marker to evaluate the successfulness of therapy
  • Therapy target
    ANIMAL & CELL MODELS