Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | GRIN2C | contributors: mct - updated : 13-03-2012 |
HGNC name | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
HGNC id | 4587 |
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Location | 17q25.1 Physical location : 72.838.167 - 72.856.007 |
Synonym name | |
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Synonym symbol(s) | NMDAR2C, NR2C, GluN2C |
DNA |
TYPE | functioning gene |
STRUCTURE | 17.84 kb 13 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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text | four isoforms (NR2C-1 to NR2C-4) (PMID: 9798920) |
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EXPRESSION |
Type | widely |
tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal |
Text | brain |
PROTEIN |
PHYSICAL PROPERTIES | Hydrophilic | |
STRUCTURE |
motifs/domains
| |
|
mono polymer | heteromer , dimer |
HOMOLOGY |
interspecies | homolog to murine Grin2c |
homolog to C.elegans Y71f9al.17 |
Homologene |
FAMILY | |
|
CATEGORY | receptor membrane , transport channel |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | post synaptic membrane |
basic FUNCTION | |
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CELLULAR PROCESS | cell life, cell death/apoptosis |
PHYSIOLOGICAL PROCESS | development , nervous system |
text | small molecule transport |
PATHWAY |
metabolism |
signaling | neurotransmission |
glutamate signaling pathway |
a component | |
| |
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INTERACTION |
DNA |
RNA |
small molecule | metal binding, |
protein | |
| |
| |
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cell & other |
REGULATION |
activated by | selectively activated by the artificial glutamate analog N-methyl D-aspartate |
Phosphorylated by | PKB/Akt, that directly phosphorylates GRIN2C on serine 1096 (S1096) |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |
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