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FLASH GENE
Symbol GRIK5 contributors: mct - updated : 08-04-2019
HGNC name glutamate receptor, ionotropic, kainate 5
HGNC id 4583
Location 19q13.2      Physical location : 42.502.472 - 42.569.957
Synonym name
  • excitatory amino acid receptor 2
  • glutamate receptor KA2
  • Synonym symbol(s) GLUR2, EAA2, GRIK2, KA2, GluK5
    DNA
    TYPE functioning gene
    STRUCTURE 73.49 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    LOC283855 19q13.31 similar to tropomyosin 3 PLEKHA3P1 19 pleckstrin homology domain-containing, family A member 3 pseudogene 1 R29124_1 19q13.31 hypothetical protein R29124_1 CEACAMP3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 3 CEACAM4 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 4 CEACAM7 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM5 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM6 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 3 LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2 DEDD2 19q13.31 POU domain, class 2, transcription factor 2 KIAA1951 GSK3A 19q13.2 glycogen synthase kinase 3 alpha ERF 19q13.1 Ets2 repressor factor CIC 19q13.2 capicua homolog (Drosophila) PAFAH1B3 19q13.1 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3331 - 981 - 2013 23288040
    18 - 3551 - 980 - 2013 23288040
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel     Homo sapiens
    Lymphoid/Immunelymph node   highly
    Nervousspinal cord   highly Mus musculusFetal
     spinal cordposterior horn    Mus musculusAdult
    Reproductivemale systemtestis  highly
    Respiratoryrespiratory tractlarynx  highly
    Visualeyeretina  highly Mus musculusFetal
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell Homo sapiens
    Visualcone photoreceptor Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments (4TM)
  • ER-retention motif within the cytosolic domain
  • HOMOLOGY
    Homologene
    FAMILY glutamate-gated ionic channel family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    text concentrated to a greater degree on postsynaptic membranes
    basic FUNCTION
  • glutamate receptor KA2, ionotropic, kainate (2-carboxy-4-(1-methenylethenyl)-3-pyrrolidinacetic) class
  • acting as an excitatory neurotransmitter at many synapses in the central nervous system
  • glutamate-binding receptor that has been implicated in the regulation of neurotransmission in the brain and sensory organs
  • likely linked to the patterning and maintenance of the vasculature
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component homomeric associations do not produce any channel activity
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with GRIK1 (both edited and unedited versions), GRIK2, or GRIK3 to form functional channels
  • interacting with GRIK2, GRIK1 AND KIF17
  • CAMK2A, CAMK2B-dependent phosphorylation of GRIK5 is responsible for synaptic depression by untrapping of kainate receptors (KARs) from the PSD and increased diffusion away from synaptic sites
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of GRIK4, and GRIK5 in the hippocampus of patients with temporal lobe epilepsy (TLE)
    constitutional     --low  
    reduced genetically predicted expression of GRIK5 with comorbid vascular and eye diseases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Grik5-deficient embryos fail to pattern blood vessels in the brain, and this failure results in fewer, smaller branches