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FLASH GENE
Symbol GRIK4 contributors: mct/npt - updated : 16-05-2019
HGNC name glutamate receptor, ionotropic, kainate 4
HGNC id 4582
Location 11q23.3      Physical location : 120.531.027 - 120.856.969
Synonym name
  • excitatory amino acid receptor 1
  • glutamate receptor KA1
  • Synonym symbol(s) EAA1, GRIK, KA1, GluK4
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 477.06 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    USP2 11q23.3 ubiquitin specific protease 2 LOC94105 11q22.3-q23 Thy-1 co-transcribed THY1 11q23.3 Thy-1 cell surface antigen LOC387813 11 similar to keratin 8; cytokeratin 8; keratin, type II cytoskeletal 8 PVRL1 11q23-q24 poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin) LOC390255 11 similar to HLA-B-associated transcript 1A; nuclear RNA helicase Bat1 LOC387814 11 LOC387814 TRIM29 11q22-q23 tripartite motif-containing 29 LOC219908 11q23.3 hypothetical LOC219908 NS5ATP13TP2 11q23.3 NS5ATP13TP2 protein POU2F3 11q23.3 POU domain, class 2, transcription factor 3 MGC17839 11q23.3 hypothetical protein MGC17839 ARHGEF12 11q23.3 Rho guanine nucleotide exchange factor (GEF) 12 GRIK4 11q23 glutamate receptor, ionotropic, kainate 4 MGC10233 11q23.3 hypothetical protein MGC10233 TECTA 11q22-q24 tectorin alpha SC5DL 11q24.2-q24.3 sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like LOC283155 11q23.3 similar to bone morphogenetic protein receptor, type IA precursor; activin A receptor, type II-like kinase 3 LOC390256 11 similar to programmed cell death-2/Rp8 homolog SORL1 11q23.2-q24.4 sortilin-related receptor, L(DLR class) A repeats-containing
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 5730 105 956 - 1994 7527545
    20 - 5770 105 956 - 1994 7527545
    18 - 3057 - 765 - 1994 7527545
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus   Homo sapiens
     brainhindbraincerebellum   Homo sapiens
    Reproductivefemale systemuterus   
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments (4TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • glutamate-gated ionic channel family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text predominantly showed presynaptic localization
    basic FUNCTION
  • acting as an excitatory neurotransmitter at many synapses in the central nervous system
  • GRIK4 may act through the JNK pathway to regulate the molecular cascades that lead to excitotoxicity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members
  • heteromeric channel with GRIK1 or GRIK3
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    of GRIK4, and GRIK5 in the hippocampus of patients with temporal lobe epilepsy (TLE)
    constitutional     --over  
    enhances synaptic transmission, causing a persistent imbalance in inhibitory and excitatory activity and disturbing the circuits responsible for the main amygdala outputs
    Susceptibility
  • to schizophrenia
  • to bipolar disorder
  • to Major depressive disorder (MDD)
  • Variant & Polymorphism other
  • haplotypes significantly associated with increased risk of schizophrenia and decreased risk of bipolar disorder, respectively
  • rs56275759 of GRIK4 gene might be associated with MDD
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice overexpressing Grik4 in the forebrain displayed social impairment, enhanced anxiety, and depressive states, accompanied by altered synaptic transmission, showing more efficient information transfer through the hippocampal trisynaptic circuit
  • GluK4 knockout mice also showed marked hyperactivity and impaired pre-pulse inhibition, thereby mirroring two of the hallmark endophenotypes of patients with schizophrenia and bipolar disorder