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FLASH GENE
Symbol GRIA3 contributors: mct/pgu - updated : 13-11-2013
HGNC name glutamate receptor, ionotrophic, AMPA 3
HGNC id 4573
Corresponding disease
MRXS29 mental retardation, syndromic 29
Location Xq25      Physical location : 122.318.095 - 122.624.760
Synonym name
  • glutamate receptor 3
  • glutamate receptor C
  • AMPA-selective glutamate receptor 3
  • glutamate receptor ionotropic, AMPA 3
  • AMPA-selective glutamate receptor 3
  • Synonym symbol(s) GLUR3, GLURC, AMPA 3, GLUR-C, GLUR-K3, dJ1171F9.1, GLUA3, MRX94
    DNA
    TYPE functioning gene
    STRUCTURE 306.67 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    text with flip and flop isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 splicing 5195 98 894 - 2007 17989220
    alsos called FLOP
    16 - 5195 98 894 - 2007 17989220
    also called FLIP
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Nervousbrain   highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye lens, eye anterior segment, retina foveal, macular, RPE, choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ligand binding site in the N terminal region
  • four transmembrane segments, one of which forming the wall of the channel
  • a large intracellular loop
  • HOMOLOGY
    interspecies homolog to murine Gria3
    Homologene
    FAMILY
  • ligand-gated ionic channels family
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • ligand gated ion (Cl) channel, mediating the fast component of excitatory post synaptic currents in the central nervous system
  • involved in neurite outgrowth, early neuronal cell development, neuropeptide signaling/synthesis and neuronal receptor
  • plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1
  • with GRIA2, GRIA1, GRIN2B, mediate fast synaptic transmission in the brain
  • role in the modulation of social behavior through brain dopamine and/or serotonin signaling and different AMPA receptor subunits affect social behavior through distinct mechanisms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and signaling through the protein-kinase LYN, PRKCABP
  • GRIA3 could be confirmed as a downstream effector of CUX1 and was expressed in pancreatic cancer tissues
  • interacting with GRIP1 and GRIP2 (bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRXS29
    Susceptibility
  • to schizophrenia among females but not in males
  • to migraine with aura
  • Variant & Polymorphism other
  • carriers of rs1034428 A allele have a 2.19-fold higher risk of developing schizophrenia compared to non-carriers and 3.28-fold higher risk for developing a non-paranoid phenotype
  • GRIA3 (rs3761555) genes strongly associated with migraine with aura
  • Candidate gene
  • for X-linked mental retardation (severely reduced GRIA3 expression results in mental retardation)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking GluA1 showed a reduced anxiety and male aggression.