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FLASH GENE

Symbol

GRIA2

contributors: mct/shn - updated : 08-11-2015

HGNC name	glutamate receptor, ionotropic, AMPA 2
HGNC id	4572

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	NEDLIB neurodevelopmental disorder with language impairment and behavioral abnormalities
Location	4q32.1      Physical location : 158.141.735 - 158.287.224
Synonym name	AMPA-selective glutamate receptor 2
	glutamate receptor 2
Synonym symbol(s)	GLUR2, GLURB, HBGR2, GluR-K2, GLUA2

DNA

TYPE	functioning gene
STRUCTURE	145.50 kb     16 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D4S1585 - D4S1589 - GRIA2 - D4S413 - D4S3351 - qter

RNA

TRANSCRIPTS	type	messenger

text	with flip and flop isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000826 16 - 5755 NP_000817 - 883 - - also called flip isoform NM_001083620 16 - 5266 NP_001077089 93.7 836 - - NM_001083619 16 - 5755 NP_001077088 - 883 - - also called flop isoform

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus       brain diencephalon amygdala

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	ligand binding site in the N terminal region
	four transmembrane segments (4TM),one of which forming the wall of the channel
	a large intracellular loop

isoforms

Precursor

with flip and flop isoforms

HOMOLOGY

interspecies	ortholog to Gria2, Mus musculus
	ortholog to Gria2, Rattus norvegicus
	ortholog to GRIA2, Pan troglodytes

Homologene

FAMILY	glutamate-gated ion channel family
	GRIA2 subfamily

CATEGORY

receptor membrane , transport channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	expressed on neuronal the plasma membranes on the external surfaces of soma, dendrites, and spines (
	expressed in recycling endosomes (

basic FUNCTION	glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class, mediating the fast component of excitatory post synaptic currents in the central nervous system
	the plasma membrane delivery of GRIA2 containing AMPA receptors is regulated by its unique structural elements (
	with GRIA1, GRIA3, GRIN2B, mediate fast synaptic transmission in the brain
	regulates metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) and is indispensable for mGluR-LTD in the hippocampus (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-binding protein (ABP) (
	protein interacting with C kinase, PICK1 (
	GluR1, 3 and 4 (
	syntenin (
	N-ethylmaleimide-sensitive factor, NSF (
	interacting with and signaling through the protein-kinase LYN, PRKCABP
	on GRIA2, B3GAT1 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
	GRIP1 and GRIP2 (bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits)
	GRIA2-PICK1 interactions are a key component of the effects of APP on synapses
	activity-dependent trafficking of GRIP1 to synaptic sites drives the forward trafficking and enhanced synaptic accumulation of GRIA2-containing AMPAR during synaptic scaling up
	CPT1C binds GRIA1 and GRIA2 and that the three proteins have the same expression profile during neuronal maturation
	dual roles for PACSIN1 in controlling the internalization and recycling of GRIA2 after NMDAR activation

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NEDLIB

Susceptibility

to amyotrophic lateral sclerosis

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Crossbreeding of the hSOD1G93A transgenic mouse model of ALS with chat-GluR2 mice led to marked delay of disease onset and mortality (
	expression of the GRIA2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex of aged rat (
	GluR2 heterozygous knock-in mouse display severe and progressive neurological deficits including seizures and, ultimately, increased mortality (