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FLASH GENE
Symbol GRIA2 contributors: mct/shn - updated : 08-11-2015
HGNC name glutamate receptor, ionotropic, AMPA 2
HGNC id 4572
Location 4q32.1      Physical location : 158.141.735 - 158.287.224
Synonym name
  • AMPA-selective glutamate receptor 2
  • glutamate receptor 2
  • Synonym symbol(s) GLUR2, GLURB, HBGR2, GluR-K2, GLUA2
    DNA
    TYPE functioning gene
    STRUCTURE 145.50 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D4S1585 - D4S1589 - GRIA2 - D4S413 - D4S3351 - qter
    RNA
    TRANSCRIPTS type messenger
    text with flip and flop isoforms
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5755 - 883 - -
    also called flip isoform
    16 - 5266 93.7 836 - -
    16 - 5755 - 883 - -
    also called flop isoform
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbraindiencephalonhypothalamus  
     braindiencephalonamygdala  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ligand binding site in the N terminal region
  • four transmembrane segments (4TM),one of which forming the wall of the channel
  • a large intracellular loop
  • isoforms Precursor with flip and flop isoforms
    HOMOLOGY
    interspecies ortholog to Gria2, Mus musculus
    ortholog to Gria2, Rattus norvegicus
    ortholog to GRIA2, Pan troglodytes
    Homologene
    FAMILY
  • glutamate-gated ion channel family
  • GRIA2 subfamily
  • CATEGORY receptor membrane , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • expressed on neuronal the plasma membranes on the external surfaces of soma, dendrites, and spines (
  • expressed in recycling endosomes (
  • basic FUNCTION
  • glutamate receptor,subunit 2,ionotropic,AMPA (amino-3-hydroxy 5 methyl-isoxazole-propionic) class, mediating the fast component of excitatory post synaptic currents in the central nervous system
  • the plasma membrane delivery of GRIA2 containing AMPA receptors is regulated by its unique structural elements (
  • with GRIA1, GRIA3, GRIN2B, mediate fast synaptic transmission in the brain
  • regulates metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) and is indispensable for mGluR-LTD in the hippocampus (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-binding protein (ABP) (
  • protein interacting with C kinase, PICK1 (
  • GluR1, 3 and 4 (
  • syntenin (
  • N-ethylmaleimide-sensitive factor, NSF (
  • interacting with and signaling through the protein-kinase LYN, PRKCABP
  • on GRIA2, B3GAT1 regulates cell surface stability of GRIA2 by modulating the interaction with CDH2
  • GRIP1 and GRIP2 (bind to the C-termini of AMPA-R GRIA2 and GRIA3 subunits)
  • GRIA2-PICK1 interactions are a key component of the effects of APP on synapses
  • activity-dependent trafficking of GRIP1 to synaptic sites drives the forward trafficking and enhanced synaptic accumulation of GRIA2-containing AMPAR during synaptic scaling up
  • CPT1C binds GRIA1 and GRIA2 and that the three proteins have the same expression profile during neuronal maturation
  • dual roles for PACSIN1 in controlling the internalization and recycling of GRIA2 after NMDAR activation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to amyotrophic lateral sclerosis
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Crossbreeding of the hSOD1G93A transgenic mouse model of ALS with chat-GluR2 mice led to marked delay of disease onset and mortality (
  • expression of the GRIA2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex of aged rat (
  • GluR2 heterozygous knock-in mouse display severe and progressive neurological deficits including seizures and, ultimately, increased mortality (