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FLASH GENE
Symbol GRHPR contributors: npt/ - updated : 30-12-2003
HGNC name glyoxylate reductase/hydroxypyruvate reductase
HGNC id 4570
Corresponding disease
PHXL2 hyperoxaluria primary type II
Location 9q13.2      Physical location : 37.422.706 - 37.436.986
Synonym name glycerate-2-dehydrogenase
Synonym symbol(s) GLRX, PH2, GLYD
EC.number 1.1.1.79,1.1.1.26
DNA
TYPE functioning gene
STRUCTURE 14.28 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC392310 9 similar to Phosphoglycerate mutase 1 (Phosphoglycerate mutase isozyme B) (PGAM-B) (BPG-dependent PGAM 1) OR2S2 9p13.3-p13.1 olfactory receptor, family 2, subfamily S, member 2 LOC389719 9 hypothetical gene supported by M24070; NM_004559 LOC392311 9 similar to seven transmembrane helix receptor OR13C7P 9 olfactory receptor, family 13, subfamily C, member 7 pseudogene LOC392313 9 similar to olfactory receptor RECK 9p13-p12 reversion-inducing-cysteine-rich protein with kazal motifs C9orf19 9p12-p13 chromosome 9 open reading frame 19 CCIN 9p13-p12 calicin CLTA 9p13-p12 clathrin, light polypeptide (Lca) GNE 9p13-p12 clathrin, light polypeptide (Lca) LOC392314 9 similar to high mobility group protein homolog HMG4 RNF38 9p13-p12 ring finger protein 38 MRPS21P4 9p13.1 mitochondrial ribosomal protein S21 pseudogene 4 MELK 9p11.2 maternal embryonic leucine zipper kinase PAX5 9p13 paired box gene 5 (B-cell lineage specific activator protein) LOC389720 9 LOC389720 LOC392315 9 similar to 60S ribosomal protein L32 FLJ22611 GRHPR 9q11.2-q12 glyoxylate reductase/hydroxypyruvate reductase ZBTB5 9p13.1 zinc finger and BTB domain containing 5 LOC158237 9p13.1 similar to potassium channel tetramerisation domain containing 9 PAF53 9p13.1 RNA polymerase I associated factor 53 FBXO10 9p12 F-box only protein 10 LOC389721 9 similar to RAB1B, member RAS oncogene family; small GTP-binding protein FRMPD1 9p13.1 FERM and PDZ domain containing 1 FLJ31455 9p13.1 hypothetical protein FLJ31455 RRP40 9p11 exosome component Rrp40 MRPS10P5 9p12 exosome component Rrp40 MGC10765 9p13.1 hypothetical protein MGC10765 MCART1 9p13.3-p12 mitochondrial carrier triple repeat 1 SHB 9p12-p11 SHB (Src homology 2 domain containing) adaptor protein B ALDH1B1 9p13 aldehyde dehydrogenase 1 family, member B1 LOC347252 9p12 similar to bA113O24.1 (similar to insulin-like growth factor binding protein) LOC340501 9p12 similar to transcription elongation factor IIS - mouse LOC340502 9p12 similar to GAS2-related protein isoform beta FLJ35740 9p12 FLJ35740 protein LOC392316 9 similar to SNAG1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1235 35.5 328 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal catalytic domain
  • a cofactor binding domain
  • mono polymer dimer
    HOMOLOGY
    Homologene
    FAMILY
  • D-isomer specific 2-hydroxyacid dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • enzyme with reductase/D-glycerate dehydrogenase activies, NADPH dependent
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • symmetrical dimeric
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHXL2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS