Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GREB1 contributors: mct - updated : 17-04-2014
HGNC name growth regulation by estrogen in breast cancer 1
HGNC id 24885
Location 2p25.1      Physical location : 11.674.241 - 11.782.912
Genatlas name gene regulated in breast cancer 1
Synonym name
  • gene regulated by estrogen in breast cancer protein
  • Synonym symbol(s) KIAA0575
    DNA
    TYPE functioning gene
    STRUCTURE 108.67 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    alternative promoter
    Binding site   transcription factor   hormone   HRE
    text structure
  • alternative promoters regulated by beta estradiol
  • three consensus estrogen response elements (EREs) spread over approximately 20 kb of upstream flanking sequences
  • putative promoter containing potential androgen receptor (AR) response elements
  • MAPPING cloned N linked N status provisional
    Physical map
    LOC129642 2p25.2 hypothetical protein BC016005 DDEF2 2p24 development and differentiation enhancing factor 2 ITGB1BP1 2p25.2 integrin beta 1 binding protein 1 CPSF3 2pter-p25 cleavage and polyadenylation specific factor 3, 73kDa LOC285148 2p25.2 hypothetical protein LOC285148 ADAM17 2p25 a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) YWHAQ 2p25 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide TAF1B 2p25 TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa TFCP2L2 2p25.1 transcription factor CP2-like 2 TIEG2 2p25 TGFB inducible early growth response 2 RRM2 2p24 ribonucleotide reductase M2 polypeptide FLJ25102 2p25.1 hypothetical protein FLJ25102 HPCAL1 2p25.1 hippocalcin-like 1 ODC1 2p25 ornithine decarboxylase 1 LOC130063 2p25.1 hypothetical gene LOC130063 FLJ14075 2p25.1 hypothetical protein FLJ14075 ATP6V1C2 2p25.1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C isoform 2 P5 2p25.1 protein disulfide isomerase-related protein LOC388924 2 LOC388924 KCNF1 2p25 potassium voltage-gated channel, subfamily F, member 1 FLJ33534 2p25.1 hypothetical protein FLJ33534 LOC391351 2 similar to RPL6 protein FLJ25143 2p25.1 hypothetical protein FLJ25143 MGC33602 ROCK2 2p24 Rho-associated, coiled-coil containing protein kinase 2 LOC391352 2 similar to peptidyl-Pro cis trans isomerase E2F6 22q11.2 E2F transcription factor 6 GREB1 2p25.1 E2F transcription factor 6 NTSR2 2p25.1 neurotensin receptor 2 LPIN1 2p25.1 lipin 1 FAM10A3 2p25.1 family with sequence similarity 10, member A3 LOC151261 2p25.1 hypothetical LOC151261 TRB2 2p25.1 tribbles homolog 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 8482 - 1949 - 2006 16496412
    GREB1a
    11 splicing 2347 - 457 - 2006 16496412
    10 splicing 2334 - 409 - 2006 16496412
    GREB1 c
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly
     male systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • play an important role in hormone-responsive tissues and cancer
  • play a pivotal role in hormone-stimulated breast cancer growth
  • may be critically involved in prostate cancer proliferation
  • unexpected role for GREB1 as an estrogen-specific ESR1 cofactor that is expressed in drug-sensitive contexts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in breast cancer cells, NR5A2 promotes cell proliferation by enhancing ESR1 mediated transcription of target genes such as GREB1
  • is a chromatin-bound ESR1 coactivator and is essential for ESR1-mediated transcription, because it stabilizes interactions between ESR1 and additional cofactors
  • cell & other
    REGULATION
    induced by ESR1
    Other regulated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in estrogen-responsive positive breast cancersand prostate carcinoma
    tumoral     --over  
    promotes cell proliferation and increases the clonogenic ability in breast cancer cells
    Susceptibility to hypertension
    Variant & Polymorphism SNP 45718A>G, was significantly associated with hypertension and blood pressure level in men
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    novel gene target for therapeutic intervention
    ANIMAL & CELL MODELS